119391-64-9Relevant articles and documents
Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists
Bongartz, Jean-Pierre,Buntinx, Mieke,Coesemans, Erwin,Hermans, Bart,Lommen, Guy Van,Wauwe, Jean Van
scheme or table, p. 5819 - 5823 (2009/06/30)
The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-cholinergic activity and identification of the key pharmacophore moieties of the series.
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist
Wilson,Dannals,Ravert,Frost,Wagner Jr.
, p. 1057 - 1062 (2007/10/02)
A series of halogenated racemic analogues of dexetimide (1) was synthesized and their affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide (21), was efficiently labeled with 125I and 123I at high