1194041-97-8

Basic information

• Product Name: 1-(3-nitrophenylsulfonyl)-3-methyl-1H-indole
• Synonyms: 1-(3-nitrophenylsulfonyl)-3-methyl-1H-indole
• CAS NO: 1194041-97-8
• Molecular Weight: 316.337
• Mol File: 1194041-97-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-nitrophenylsulfonyl)-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-nitrophenylsulfonyl)-3-methyl-1H-indole(1194041-97-8)
• EPA Substance Registry System: 1-(3-nitrophenylsulfonyl)-3-methyl-1H-indole(1194041-97-8)

Safety Data

• Hazardous Substances Data: 1194041-97-8(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 121-51-7 3-nitrobenzenesulphonyl chloride 

Relevant articles and documents

ZnO-mediated regioselective C-arylsulfonylation of indoles: A facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)

A ZnO-mediated one-pot solvent-free protocol for the regioselective C-arylsulfonylation of indoles is described and some novel derivatives were tested on wild type and non-nucleoside inhibitor resistant K103N and Y181C HIV-1 reverse transcriptases (RTs).

Anti human immunodeficiency virus-1 (HIV-1) agents 3. Synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles

In order to find compounds with superior anti human immunodeficiency virus type 1 (HIV-1) activity, twelve simple N-arylsulfonylindoles (3a-l) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Several compounds demonstrated significant anti-HIV-1 activity, especially N-(3-nitrobenzene) sulfonyl-6-methylindole (3h) and N-(3-nitrobenzene)sulfonylindole (3i) showed the highest anti-HIV-1 activity with EC50 values of 0.26 and 0.74 μg/ml, and TI values of 543.78 and >270.27, respectively.