119520-52-4

Basic information

• Product Name: N-(pyridin-3-yl)cyclohexanecarboxamide
• Synonyms: N-(pyridin-3-yl)cyclohexanecarboxamide
• CAS NO: 119520-52-4
• Molecular Weight: 204.272
• Mol File: 119520-52-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(pyridin-3-yl)cyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(pyridin-3-yl)cyclohexanecarboxamide(119520-52-4)
• EPA Substance Registry System: N-(pyridin-3-yl)cyclohexanecarboxamide(119520-52-4)

Safety Data

• Hazardous Substances Data: 119520-52-4(Hazardous Substances Data)

Upstream product

• 10296-29-4 3-azidopyridine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 626-60-8 3-Chloropyridine 
• 1122-56-1 cyclohexylcarboxamide 
• 85526-38-1 3-pyridyl isocyanide 
• 462-08-8 pyridin-3-ylamine 
• 119541-42-3 N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 98-89-5 Cyclohexanecarboxylic acid 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 

Relevant articles and documents

Synthesis of NCA [carbonyl-11C]amides by direct reaction of in situ generated [11C]carboxymagnesium halides with amines under microwave-enhanced conditions

No-carrier-added (NCA) aromatic and aliphatic [carbonyl- 11C]amides were rapidly (11C]carboxymagnesium halides generated in situ from Grignard reagents and cyclotronproduced [11C]carbon dioxide. In this system cyclohexylcarboxymagnesium chloride (1b) is more reactive than 4-fluorophenylcarboxymagnesium bromide (2b) and primary amines (e.g. aniline, aminopyridines) far more reactive than secondary amines (e.g. 2-(methylamino)pyridine). The scope of the reaction was widened considerably by the application of microwaves, which allowed reactions to be carried out at much higher temperature than the boiling point of the solvent (i.e. tetrahydrofuran, b.p. 67°C). Copyright

Base-catalyzed synthesis of aryl amides from aryl azides and aldehydes

Aryl amides have been used as important compounds in pharmaceuticals, materials and in molecular catalysis. The methods reported to prepare aryl amides generally require very specific reagents, and the most popular carboxyl-amine coupling reactions demand stoichiometric activators. Herein, we report that aryl azides react with aldehydes under base-catalyzed conditions to yield aryl amides efficiently. Mechanistic investigations support the formation of triazoline intermediates via azide-enolate cycloaddition, which subsequently undergo rearrangement to give amides by either thermal decomposition (20-140 °C) or aqueous acid work-up at room temperature. The strategy does not require nucleophilic anilines and is especially efficient for highly electron-deficient aryl amides, including perfluoroaryl amides, which are otherwise challenging to synthesize.

THE INVENTION OF RADICAL REACTIONS PART XVIII. A CONVENIENT SOLUTION TO THE 1-CARBON PROBLEM (R-CO2H --> R-13CO2H)

Radicals generated by photolysis (W light) of esters derived from N-hydroxy-2-thiopyridone react with electrophilic isocyanides 2a and (in the presence of trifluoroacetic acid) 2b to give adducts of type 3.Convenient reaction procedures have been worked out to hydrolyse the adducts to amides of type 5, from which the original acid can be regenerated under mild conditions.The three important acids oleic, linoleic and arachidonic have all given smooth reactions.In suitable examples, quantitative evolution of carbon dioxide and incorporation of 13C without dilution have been demonstrated.This reaction sequence will be useful for the labelling in the carboxyl group of prostaglandins, leukotrienes, and the side chain carboxyls of peptides.