119520-57-9

Basic information

• Product Name: Benzenepropanamide, N-(4-nitrophenyl)-
• CAS NO: 119520-57-9
• Molecular Formula: C15H14N2O3
• Molecular Weight: 270.288
• Mol File: 119520-57-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, N-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-(4-nitrophenyl)-(119520-57-9)
• EPA Substance Registry System: Benzenepropanamide, N-(4-nitrophenyl)-(119520-57-9)

Safety Data

• Hazardous Substances Data: 119520-57-9(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 645-45-4 hydrocinnamic acid chloride 
• 104-53-0 3-phenyl-propionaldehyde 
• 1516-60-5 4-nitrophenyl azide 
• 119520-49-9 3-phenyl-N-(pyridin-3-yl)propanamide 
• 16135-31-2 p-nitroformanilide 
• 28048-94-4 2-methylpropyl 3-phenypropionate 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 1984-23-2 p-nitrophenyl isocyanide 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 1173292-04-0 3-benzyl-6-nitro-2-chloro-quinoline 
• 2021-28-5 ethyl dihydrocinnamate 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 119520-61-5 3-phenylpropanoic dithioperoxyanhydride 
• 119520-49-9 3-phenyl-N-(pyridin-3-yl)propanamide 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 77078-54-7 3-phenylthiopropionic acid 
• 83-33-0 inden-1-one 
• 28048-94-4 2-methylpropyl 3-phenypropionate 

Relevant articles and documents

Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity

Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.

Convenient synthesis of acetaminophen analogues containing α-amino acids and fatty acids via their mixed carbonic carboxylic anhydrides in aqueous organic solvent

Acetaminophen analogues containing α-amino acid and fatty acids were easily synthesized in 77-99% yields from the corresponding mixed carbonic carboxylic anhydrides of α-amino acid and fatty acids using aniline derivatives in aqueous MeCN.

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

A new series of 20 quinoline derivatives possessing triazolo, ureido and thioureido substituents have been synthesized and their antimycobacterial properties have been evaluated. Compounds 10, 22 and 24 inhibited Mycobacterium tuberculosis H37Rv up to 96%, 98% and 94% respectively, at a fixed concentration of 6.25 μg/mL. Minimum inhibitory concentration of 3.125 μg/mL was obtained for compound 10 and 24, while for compound 22 it was 6.25 μg/mL. Molecular docking calculations suggest critical hydrogen bonding and electrostatic interactions between polar functional groups (such as quinoline-nitrogen, urea-carbonyl and hydroxyl) of anti-mycobacterial (anti-TB) compounds and amino acids (Arg186 and Glu61) of ATP-synthase of M. tuberculosis, could be the probable reason for observed anti-mycobacterial action.