1195417-90-3

Basic information

• Product Name: C₄₃H₅₉N₃O₆
• CAS NO: 1195417-90-3
• Molecular Weight: 713.958
• Mol File: 1195417-90-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₃H₅₉N₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₅₉N₃O₆(1195417-90-3)
• EPA Substance Registry System: C₄₃H₅₉N₃O₆(1195417-90-3)

Safety Data

• Hazardous Substances Data: 1195417-90-3(Hazardous Substances Data)

Upstream product

• 16312-86-0 4-benzyl-1,2,4-triazolidine-3,5-dione 
• 55786-93-1 3,28-di-O-acetyl-18,19-epoxylupane 
• 1221640-63-6 3,28-diacetoxy-18,19-epoxylupane 
• 57964-81-5 4-(phenylmethyl)-3H-1,2,4-triazole-3,5(4H)-dione 

Relevant articles and documents

Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives

Betulin, a naturally occurring abundant triterpene is converted in four steps to 3,28-di-O-acetyllupa-12,18-diene. When various 4-substituted urazoles were oxidized to the corresponding urazines with iodobenzene diacetate in the presence of 3,28-di-O-acetyllupa-12,18-diene, new heterocyclic betulin derivatives were produced. These betulin derivatives were examined in a microplate assay at 50 μM for their ability to inhibit the growth of Leishmania donovani axenic amastigotes, a species that causes the fatal visceral leishmaniasis. GI50 (concentration for 50% growth inhibition) values of the most effective compounds were determined and their cytotoxicity on the human macrophage cell line THP-1 evaluated. The anti-leishmanial activity on L. donovani amastigotes growing in macrophages was also examined. The heterocycloadduct between 3,28-di-O-acetyllupa-12,18-diene and 4-methylurazine was the most effective derivative with an GI50 = 8.9 μM against L. donovani amastigotes.