1195776-73-8Relevant articles and documents
A solvent-free regioselective iodination route of ortho-carboranes
Vaca, Albert,Teixidor, Francesc,Kivekaes, Raikko,Sillanpaeae, Reijo,Vinas, Clara
, p. 4884 - 4885 (2006)
Tetraiodo-ortho-Carborane based x-ray contrast agents was prepared n a high yield, fast, clean, regioselective fashion by a solvent-free reaction of ortho-carboranes with iodine in sealed tubes. ortho-Carborane and its derivatives can be iodinated under electrophilic conditions using Lewis or Bronsted acid catalysts. The Pyrex tube was opened and gaseous HI removed by evaporation leaving the crude product as a solid. Almost all the excess iodine could be removed from the mixture by sublimation under reduced pressure avoiding the need for quenching with sodium metabisulfite and allowing further reuse of reagents. This solvent-free approach to the iodination of ortho-Carboranes is feasible and appears to be fairly generic for the synthesis of tetraiodinated products.