1195950-18-5

Basic information

• Product Name: C₁₁H₁₆ClNO
• CAS NO: 1195950-18-5
• Molecular Weight: 213.707
• Mol File: 1195950-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₆ClNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₆ClNO(1195950-18-5)
• EPA Substance Registry System: C₁₁H₁₆ClNO(1195950-18-5)

Safety Data

• Hazardous Substances Data: 1195950-18-5(Hazardous Substances Data)

Upstream product

• 2033-81-0 1-(4-bromobutoxy)-4-chlorobenzene 
• 74-89-5 methylamine 

Downstream Products

• 1146681-20-0 3-{[4-(4-chlorophenoxy)butyl](methyl)amino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol 

Relevant articles and documents

Discovery of highly potent novel antifungal azoles by structure-based rational design

On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles were designed and synthesized. All the new azoles show excellent in vitro activity against most of the tested pathogenic fungi, which represent a class of promising leads for the development of novel antifungal agents. The MIC80 value of compounds 8c, 8i and 8n against C. albicans is 0.001 μg/mL, indicating that these compounds are more potent than fluconazole, itraconazole and voriconazole. Flexible molecular docking was used to analyze the structure-activity relationships (SARs) of the compounds. The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.