119596-20-2

Basic information

• Product Name: 2-(4-isopropylphenyl)-5-methylisoindoline-1,3-dione
• Synonyms: 2-(4-isopropylphenyl)-5-methylisoindoline-1,3-dione
• CAS NO: 119596-20-2
• Molecular Weight: 293.365
• Mol File: 119596-20-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-isopropylphenyl)-5-methylisoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-isopropylphenyl)-5-methylisoindoline-1,3-dione(119596-20-2)
• EPA Substance Registry System: 2-(4-isopropylphenyl)-5-methylisoindoline-1,3-dione(119596-20-2)

Safety Data

• Hazardous Substances Data: 119596-20-2(Hazardous Substances Data)

Upstream product

• 19438-61-0 4-methylphthalic anhydride 
• 769-92-6 4-tert-Butylaniline 
• 40314-06-5 5-methyl-1H-isoindole-1,3-(2H)-dione 
• 253185-03-4 tert-butylbenzene 

Relevant articles and documents

Design and synthesis of n-phenyl phthalimides as potent protoporphyrinogen oxidase inhibitors

Protoporphyrinogen oxidase (PPO) has been identified as one of the most promising targets for herbicide discovery. A series of novel phthalimide derivatives were designed by molecular docking studies targeting the crystal structure of mitochondrial PPO from tobacco (mtPPO, PDB: 1SEZ) by using Flumioxazin as a lead, after which the derivatives were synthesized and characterized, and their herbicidal activities were subsequently evaluated. The herbicidal bioassay results showed that compounds such as 3a (2-(4-bromo-2,6-difluorophenyl)isoindoline-1,3-dione), 3d (methyl 2-(4-chloro-1,3-dioxoisoindolin-2-yl)-5-fluorobenzoate), 3g (4-chloro-2-(5-methylisoxazol-3-yl) isoindoline-1,3-dione), 3j (4-chloro-2-(thiophen-2-ylmethyl)isoindoline-1,3-dione) and 3r (2-(4-bromo-2,6-difluorophenyl)-4-fluoroisoindoline-1,3-dione) had good herbicidal activities; among them, 3a showed excellent herbicidal efficacy against A. retroflexus and B. campestris via the small cup method and via pre-emergence and post-emergence spray treatments. The efficacy was comparable to that of the commercial herbicides Flumioxazin, Atrazine, and Chlortoluron. Further, the enzyme activity assay results suggest that the mode of action of compound 3a involves the inhibition of the PPO enzyme, and 3a showed better inhibitory activity against PPO than did Flumioxazin. These results indicate that our molecular design strategy contributes to the development of novel promising PPO inhibitors.