1195961-07-9

Basic information

• Product Name: 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid
• Synonyms: 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid
• CAS NO: 1195961-07-9
• Molecular Weight: 264.305
• Mol File: 1195961-07-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid(1195961-07-9)
• EPA Substance Registry System: 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid(1195961-07-9)

Safety Data

• Hazardous Substances Data: 1195961-07-9(Hazardous Substances Data)

Upstream product

• 721-66-4 glycylphenylalanine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 1195960-92-9 2-(4-(5-bromo-2-oxoindolin-3-ylidene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-96-3 2-(4-((5-(4-chlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-93-0 2-(4-(5-bromo-6-chloro-2-oxoindolin-3-ylidene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-95-2 2-(4-((5-(4-methoxyphenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-00-2 2-(4-((5-(4-fluorophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-94-1 2-(4-((5-(4-chlorophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-08-0 (E)-2-(4-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-97-4 2-(4-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-02-4 (E)-2-(4-((5-(4-bromophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195960-98-5 2-(4-((5-(4-bromophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-03-5 (E)-2-(4-((5-(4-bromo-3-chlorophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-01-3 (E)-2-(4-((5-(4-bromo-3-chlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-04-6 2-(4-((5-(4-trifluoromethoxyphenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1195961-06-8 2-(-4-((5-(4-iodophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 

Relevant articles and documents

Discovery of novel putative inhibitors of UDP-GlcNAc 2-epimerase as potent antibacterial agents

We present the discovery and optimization of a novel series of inhibitors of bacterial UDP-N-acetylglucosamine 2-epimerase (called 2-epimerase in this letter). Starting from virtual screening hits, the activity of various inhibitory molecules was optimized using a combination of structure-based and rational design approaches. We successfully designed and identified a 2-epimerase inhibitor (compound 12-ES-Na, that we named Epimerox), which blocked the growth of methicillin-resistant Staphylococcus aureus (MRSA) at 3.9 μM MIC (minimum inhibitory concentration) and showed potent broad-range activity against all Gram-positive bacteria that were tested. Additionally a microplate coupled assay was performed to further confirm that the 2-epimerase inhibition of Epimerox was through a target-specific mechanism. Furthermore, Epimerox demonstrated in vivo efficacy and had a pharmacokinetic profile that is consonant with it being developed into a promising new antibiotic agent for treatment of infections caused by Gram-positive bacteria.