1195983-88-0

Basic information

• Product Name: H-MeAla-Phe-Leu-NH₂
• CAS NO: 1195983-88-0
• Molecular Weight: 362.472
• Mol File: 1195983-88-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-MeAla-Phe-Leu-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: H-MeAla-Phe-Leu-NH₂(1195983-88-0)
• EPA Substance Registry System: H-MeAla-Phe-Leu-NH₂(1195983-88-0)

Safety Data

• Hazardous Substances Data: 1195983-88-0(Hazardous Substances Data)

Upstream product

• 112883-29-1 N-Fmoc-Tyr-OH 
• 84000-07-7 N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine 

Relevant articles and documents

Oxyma: An efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion

Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has been tested as an additive for use in the carbodiimide approach for formation of peptide bonds. Its performance in relation to those of HOBt and HOAt, which have recently been reported to exhibit explosive properties, is reported. Oxyma displayed a remarkable capacity to inhibit racemization, together with im-pressive coupling efficiency in both automated and manual synthesis, superior to those of HOBt and at least comparable to those of HOAt, and surpassing the latter coupling agent in the more demanding peptide models. Stability assays showed that there was no risk of capping the resin under standard coupling conditions. Finally, calorimetry assays (DSC and ARC) showed decomposition profiles for benzotriazolebased additives that were consistent with their reported explosivities and suggested a lower risk of explosion in the case of Oxyma.