1195985-63-7

Basic information

• Product Name: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone
• Synonyms: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone
• CAS NO: 1195985-63-7
• Molecular Weight: 250.685
• Mol File: 1195985-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone(1195985-63-7)
• EPA Substance Registry System: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone(1195985-63-7)

Safety Data

• Hazardous Substances Data: 1195985-63-7(Hazardous Substances Data)

Upstream product

• 1195985-62-6 methyl 1-(3-chlorophenyl)-5-methoxy-1H-pyrazole-3-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 55983-75-0 1-(3-chlorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 1195985-44-4 (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine 

Relevant articles and documents

Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl) methanamines as potent and efficacious type II calcimimetics

Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects on the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.