1196049-18-9

Basic information

• Product Name: (-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol
• CAS NO: 1196049-18-9
• Molecular Weight: 213.074
• Mol File: 1196049-18-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol(1196049-18-9)
• EPA Substance Registry System: (-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol(1196049-18-9)

Safety Data

• Hazardous Substances Data: 1196049-18-9(Hazardous Substances Data)

Usage

Description

(-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol, also known as bromoindaneol, is a chiral brominated indene derivative with a molecular formula C9H9BrO. It is a chemical compound that possesses a unique chiral structure, which makes it a valuable building block for the synthesis of pharmaceutical and agrochemical products.

Uses

Used in Pharmaceutical Industry:
(-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol is used as a building block for the synthesis of various pharmaceutical products due to its unique chiral structure and potential biological activities, including antitumor and antiparasitic properties.
Used in Agrochemical Industry:
(-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol is used as a building block for the synthesis of agrochemical products, contributing to the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
(-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol is used as a reagent in organic synthesis, taking advantage of its unique chiral structure to create enantioselective reactions and produce desired chiral compounds.
Used in Chemical Reactions:
(-)-(R)-7-bromo-2,3-dihydro-1H-inden-1-ol is utilized in chemical reactions as a reagent, leveraging its specific properties to facilitate desired transformations and syntheses in the chemical research and development process.

Upstream product

• 125114-77-4 7-bromo-2,3-dihydro-1H-inden-1-one 
• 124-73-2 1,2-dibromo-1,1,2,2-tetrafluoroethane 
• 6351-10-6 1-Indanol 

Downstream Products

• 125114-77-4 7-bromo-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

The Discovery of (S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H -inden-4-yl)pyridin-2-yl)-5-methyl-1 H -pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma

Soluble guanylate cyclase (sGC), the endogenous receptor for nitric oxide (NO), has been implicated in several diseases associated with oxidative stress. In a pathological oxidative environment, the heme group of sGC can be oxidized becoming unresponsive to NO leading to a loss in the ability to catalyze the production of cGMP. Recently a dysfunctional sGC/NO/cGMP pathway has been implicated in contributing to elevated intraocular pressure associated with glaucoma. Herein we describe the discovery of molecules specifically designed for topical ocular administration, which can activate oxidized sGC restoring the ability to catalyze the production of cGMP. These efforts culminated in the identification of compound (+)-23, which robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop and has been selected for clinical evaluation.

INDANE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.