119614-71-0

Basic information

• Product Name: trimethyl(((3R,6R)-6-methyl-3-(prop-1-en-2-yl)cyclohex-1-en-1-yl)oxy)silane
• Synonyms: trimethyl(((3R,6R)-6-methyl-3-(prop-1-en-2-yl)cyclohex-1-en-1-yl)oxy)silane
• CAS NO: 119614-71-0
• Molecular Weight: 224.418
• Mol File: 119614-71-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trimethyl(((3R,6R)-6-methyl-3-(prop-1-en-2-yl)cyclohex-1-en-1-yl)oxy)silane(CAS DataBase Reference)
• NIST Chemistry Reference: trimethyl(((3R,6R)-6-methyl-3-(prop-1-en-2-yl)cyclohex-1-en-1-yl)oxy)silane(119614-71-0)
• EPA Substance Registry System: trimethyl(((3R,6R)-6-methyl-3-(prop-1-en-2-yl)cyclohex-1-en-1-yl)oxy)silane(119614-71-0)

Safety Data

• Hazardous Substances Data: 119614-71-0(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 5524-05-0 (-)-dihydrocarvone 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 5524-05-0 (2R,5R)-5-isopropenyl-2-methylcyclohexanone 

Downstream Products

• 119614-72-1 (2R,3R,6S)-2-hydroxy-6-methyl-3-(prop-1-en-2-yl)cyclohexan-1-one 

Relevant articles and documents

Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators

A library of novel structural hybrids of menthol and cubebol was tested for each derivative's ability to interact with the transient receptor potential subfamily melastatin member 8 (TRPM8) channel. This structure-activity relationship study revealed three potent modulators of the TRPM8 ion channel: a novel agonist (4) with an EC50 value of 11 ± 1 μM, an antagonist (15) with an IC50 value of 2 ± 1 μM, and an allosteric modulator (21) that minimized channel desensitization toward menthol. Each of these novel exocyclic olefin analogues of menthol is readily accessible by synthesis and was tested using Ca2+ assays and electrophysiology.