119630-39-6Relevant articles and documents
The Interaction of Chlorinated 6-Spiroepoxypenicillins with Bacillus cereus &β-Lactamase I: Irreversible Inhibition and Turnover
Bycroft, Barrie W.,Gledhill, Linden,Shute, Richard E.,Williams, Paul
, p. 1610 - 1612 (1988)
The chlorinated 6-spiroepoxypenicillin anilides (1a) and (1b) are irreversible inhibitors of β-lactamase I from Bacillus cereus, but they are also turned over by this enzyme to yield the same hydrolysis product, whose structure has been revealed to be an unusual 6-substituted-1,4-dihydrothiazine-3-carboxylate, α-ketoamide; a possible pathway for the turnover and inhibitory processes associated with these interactions is presented.