1196546-61-8

Basic information

• Product Name: 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzonitrile
• Synonyms: 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzonitrile
• CAS NO: 1196546-61-8
• Molecular Weight: 419.409
• Mol File: 1196546-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzonitrile(1196546-61-8)
• EPA Substance Registry System: 4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzonitrile(1196546-61-8)

Safety Data

• Hazardous Substances Data: 1196546-61-8(Hazardous Substances Data)

Upstream product

• 6775-78-6 6-chloroimidazo[1,2-b]pyridazine 
• 13526-66-4 3-bromo-6-chloro-imidazo[1,2-b]pyridazine 
• 1196551-99-1 tert-butyl 2-(2,5-difluorophenyl)-2-hydroxypyrrole-1-carboxylate 
• 1443623-92-4 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole 
• 886503-15-7 rac-2-(2,5-difluorophenyl)pyrrolidine 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 843663-18-3 (4-cyano-3-fluorophenyl)boronic acid 
• 1196551-98-0 3-bromo-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine 

Downstream Products

• 1196546-70-9 1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Ros, KDR, FMS, c-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-1R, ALK4, ALK5 and ALK or combinations thereof.