1197196-48-7 Usage
Description
UNC 0224, also known as N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX-01294, is a selective inhibitor of G9a-like protein and G9a histone lysine methyltransferase (HMTase). It plays a crucial role in regulating gene expression and has potential applications in various fields due to its ability to modulate specific biological processes.
Uses
Used in Pharmaceutical Industry:
UNC 0224 is used as a selective inhibitor for G9a-like protein and G9a histone lysine methyltransferase (HMTase) for its potential role in regulating gene expression and influencing various biological processes. Its ability to inhibit these proteins makes it a promising candidate for the development of novel therapeutic strategies in the treatment of various diseases.
Used in Research and Development:
In the field of research and development, UNC 0224 is used as a valuable tool for studying the functions and mechanisms of G9a-like protein and G9a histone lysine methyltransferase (HMTase). By inhibiting these proteins, researchers can gain insights into their roles in cellular processes and identify potential targets for therapeutic intervention.
Used in Epigenetic Regulation:
UNC 0224 is used as an epigenetic regulator for its potential to modulate gene expression through the inhibition of G9a-like protein and G9a histone lysine methyltransferase (HMTase). This regulation can have significant implications in the development of treatments for various diseases, including cancer, by targeting specific biological pathways involved in disease progression.
Used in Drug Development:
In the drug development industry, UNC 0224 is used as a lead compound for the development of novel therapeutics targeting G9a-like protein and G9a histone lysine methyltransferase (HMTase). Its selective inhibition of these proteins can potentially lead to the creation of new drugs with improved efficacy and reduced side effects, benefiting patients with various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1197196-48-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,7,1,9 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1197196-48:
(9*1)+(8*1)+(7*9)+(6*7)+(5*1)+(4*9)+(3*6)+(2*4)+(1*8)=197
197 % 10 = 7
So 1197196-48-7 is a valid CAS Registry Number.
1197196-48-7Relevant articles and documents
Protein lysine methyltransferase g9a inhibitors: Design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu, Feng,Chen, Xin,Allali-Hassani, Abdellah,Quinn, Amy M.,Wigle, Tim J.,Wasney, Gregory A.,Dong, Aiping,Senisterra, Guillermo,Chau, Irene,Siarheyeva, Alena,Norris, Jacqueline L.,Kireev, Dmitri B.,Jadhav, Ajit,Herold, J. Martin,Janzen, William P.,Arrowsmith, Cheryl H.,Frye, Stephen V.,Brown, Peter J.,Simeonov, Anton,Vedadi, Masoud,Jin, Jian
experimental part, p. 5844 - 5857 (2010/10/03)
Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth, and the dimethylation of p53 K373 results in the inactivation of p53. Initial SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template represented by 3a (BIX01294), a selective small molecule inhibitor of G9a and GLP, led to the discovery of 10 (UNC0224) as a potent G9a inhibitor with excellent selectivity. A high resolution X-ray crystal structure of the G9a?10 complex, the first cocrystal structure of G9a with a small molecule inhibitor, was obtained. On the basis of the structural insights revealed by this cocrystal structure, optimization of the 7-dimethylaminopropoxy side chain of 10 resulted in the discovery of 29 (UNC0321) (Morrison Ki = 63 pM), which is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date.
