1197300-24-5 Usage
Description
4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylis a TGR5 receptor agonist, which is an agonist of the bile acid G protein-coupled receptor TGR5. It has the ability to stimulate cAMP formation in HEK293 cells expressing TGR5 and has been shown to increase glucagon-like peptide 1 (GLP-1) secretion and decrease glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. Additionally, it inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4.
Uses
Used in Pharmaceutical Industry:
4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylis used as a TGR5 receptor agonist for the treatment of various conditions related to glucose metabolism and bile acid regulation. Its ability to stimulate cAMP formation and increase GLP-1 secretion makes it a potential therapeutic agent for diabetes and other metabolic disorders.
Used in Drug Development:
4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylis used as a research compound for the development of new drugs targeting the TGR5 receptor. Its agonistic activity and inhibition of CYP isozymes make it a valuable tool in the design and synthesis of novel therapeutic agents for various diseases.
Used in Research Applications:
4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylis used as a research tool in cell-based assays to study the function and role of the TGR5 receptor in cellular processes. Its agonistic activity allows researchers to investigate the downstream effects of TGR5 activation and its potential role in various physiological and pathological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1197300-24-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,7,3,0 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1197300-24:
(9*1)+(8*1)+(7*9)+(6*7)+(5*3)+(4*0)+(3*0)+(2*2)+(1*4)=145
145 % 10 = 5
So 1197300-24-5 is a valid CAS Registry Number.
1197300-24-5Relevant articles and documents
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists
Evans, Karen A.,Budzik, Brian W.,Ross, Sean A.,Wisnoski, David D.,Jin, Jian,Rivero, Ralph A.,Vimal, Mythily,Szewczyk, George R.,Jayawickreme, Channa,Moncol, David L.,Rimele, Thomas J.,Armour, Susan L.,Weaver, Susan P.,Griffin, Robert J.,Tadepalli, Sarva M.,Jeune, Michael R.,Shearer, Todd W.,Chen, Zibin B.,Chen, Lihong,Anderson, Donald L.,Becherer, J. David,De Los Frailes, Maite,Colilla, Francisco Javier
supporting information; experimental part, p. 7962 - 7965 (2010/07/13)
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent small molecule agonists of the human TGR5 G-protein coupled receptor is described. Subsequent optimization resulted in the rapid identificatio
