1197376-85-4 Usage
Description
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride, also known as INCB28060 Dihydrochloride, is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 of 0.13 nM. It exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases.
Uses
Used in Oncology:
INCB28060 Dihydrochloride is used as an anticancer agent for c-MET-dependent tumor cell lines. It potently blocks c-MET phosphorylation and activation of its key downstream effectors, leading to the inhibition of tumor cell proliferation, migration, and induction of apoptosis in vitro.
Used in Pharmaceutical Industry:
INCB28060 Dihydrochloride is used as a research compound and drug candidate in the development of targeted therapies for cancer treatment. Its high specificity and potency make it a valuable tool for studying the role of c-MET kinase in cancer progression and for developing new treatments for c-MET-dependent tumors.
Check Digit Verification of cas no
The CAS Registry Mumber 1197376-85-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,7,3,7 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1197376-85:
(9*1)+(8*1)+(7*9)+(6*7)+(5*3)+(4*7)+(3*6)+(2*8)+(1*5)=204
204 % 10 = 4
So 1197376-85-4 is a valid CAS Registry Number.
1197376-85-4Relevant articles and documents
PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-FLUORO-N-METHYL-4-[7-QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-B][1,2,4]TRIAZIN-2YL]BENZAMIDE
-
, (2021/08/27)
The present invention relates to a novel chemical process for the synthesis of the compound 2- fluoro-N-methyl-4-[7-quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2yl]benzamide.
IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS
-
Page/Page column 45, (2008/12/05)
-