119770-38-6

Basic information

• Product Name: cis-1-methoxy-2-(4-carbomethoxyphenyl)ethylene
• Synonyms: cis-1-methoxy-2-(4-carbomethoxyphenyl)ethylene
• CAS NO: 119770-38-6
• Molecular Weight: 192.214
• Mol File: 119770-38-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: cis-1-methoxy-2-(4-carbomethoxyphenyl)ethylene(CAS DataBase Reference)
• NIST Chemistry Reference: cis-1-methoxy-2-(4-carbomethoxyphenyl)ethylene(119770-38-6)
• EPA Substance Registry System: cis-1-methoxy-2-(4-carbomethoxyphenyl)ethylene(119770-38-6)

Safety Data

• Hazardous Substances Data: 119770-38-6(Hazardous Substances Data)

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 67-56-1 methanol 
• 3034-86-4 4-ethynylbenzoic acid methyl ester 

Downstream Products

• 1612882-41-3 C₁₁H₁₃IO₂ 
• 145621-80-3 methyl (S)-(-)-p-(2-hydroxy-1-methylethyl)benzoate 
• 1612882-25-3 C₁₇H₁₆O₃S₂ 
• 1612882-15-1 C₁₇H₁₄O₃S₂ 
• 106918-32-5 4-carbomethoxyphenylacetaldehyde 

Relevant articles and documents

A straightforward organocatalytic alkylation of 2-arylacetaldehydes: An approach towards bisabolanes

A highly stereoselective organocatalytic aalkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/ water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described.

Rhodium-catalyzed anti-Markovnikov intermolecular hydroalkoxylation of terminal acetylenes

We report here the first transition-metal-catalyzed anti-Markovnikov intermolecular hydroalkoxylation of terminal acetylenes to give enol ethers in high yields without using bases. Arylacetylenes as well as alkenyl- and alkylacetylenes were coupled with aliphatic alcohols, and the products were obtained with high Z selectivity in most cases. Effective catalysts were 8-quinolinolato rhodium complexes, which are structurally simple but have been relatively unexplored as catalysts.

CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS

This invention pertains to certain carbamic acid compounds of the formula (I), which inhibit HDAC (histone deacetylase) activity: wherein: J is a linking functional group and is independently: -O-C(=O)- or -C(=O)-O- or - C(=O)-; Cy is a cyclyl group and is independently: C3-20carbocyclyl, C3-20heterocyclyl, or C5-20aryl; and is optionally substituted; Q1 is a cyclyl leader group, and is independently a divalent bidentate group obtained by removing two hydrogen atoms from a ring carbon atom of a saturated monocyclic hydrocarbon having from 4 to 7 ring atoms, or by removing two hydrogen atoms from a ring carbon atom of saturated monocyclic heterocyclic compound having from 4 to 7 ring atoms including 1 nitrogen ring atom or 1 oxygen ring atom; and is optionally substituted; Q2 is an acid leader group, and is independently: C1-8alkylene; and is optionally substituted; or: Q2 is an acid leader group, and is independently: C5-20arylene; C5-20arylene-C1-7alkylene; C1-7alkylene-C5-20arylene; or C1-7alkylene-C5-20arylene-C1-7alkylene; and is optionally substituted; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC,and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.