119775-99-4

Basic information

• Product Name: (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone
• Synonyms: (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone
• CAS NO: 119775-99-4
• Molecular Weight: 492.636
• Mol File: 119775-99-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone(119775-99-4)
• EPA Substance Registry System: (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone(119775-99-4)

Safety Data

• Hazardous Substances Data: 119775-99-4(Hazardous Substances Data)

Upstream product

• 58846-72-3 (2S)-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid methyl ester 
• 3112-85-4 methylphenylsulfonate 
• 58846-71-2 (-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate 
• 53730-39-5 (S)-(-)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-acetic acid 

Downstream Products

• 59-02-9 Tocopherol 
• 162810-67-5 (2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether 
• 119776-03-3 <2S-(4R,5E,8R)>-1-<2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-4,8,12-trimethyl-3-phenylsulfonyltrideca-2,5,11-triene 
• 59965-06-9 Vitamin E benzyl ether 

Relevant articles and documents

A MICROBIAL LIPASE BASED STEREOSELECTIVE SYNTHESIS OF (d)-α-TOCOPHEROL FROM (R)-CITRONELLAL AND (S)-(6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETIC ACID

A new sythesis of natural vitamin E (2R,4'R,8'R)-α-tocopherol) based on (R)-citronellal and (S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid is described.The citronellal is elaborated into an optically pure C13 allylic carbonate using a lipase catalyzed kinetic resolution to control the new chiral center.Palladium catalyzed coupling of the C13 carbonate with either a β-ketoester or β-ketosulphone derived from the chromanylacetic completes the assembly of the α-tocopherol skeleton.Appropriate functional group modifications are used to complete the synthesis.