119786-13-9Relevant articles and documents
An efficient chemo-enzymatic approach to the enantioselective synthesis of 2-methyl-1,3-propamedical derivatives
Santaniello, Enzo,Ferraboschi, Patrizia,Grisenti, Paride
, p. 5657 - 5660 (1990)
Lipase-catalyzed transesterification of 2-methyl-1,3-propanediol 1 in chloroform affords enantiomerically pure (S)-(-)-acetate 2, from which the (R)-(+)-silyl ethers 4a-b can be efficiently prepared (>98% ee). The (S)-TBDPS derivative 4b could be also efficiently and enantioselectively prepared by the same enzymatic procedure, starting from racemic 5b.