119788-62-4

Basic information

• Product Name: (2R*,3S*)-2-Hydroxy-1,3-diphenyl-1-butanon
• Synonyms: (2R*,3S*)-2-Hydroxy-1,3-diphenyl-1-butanon
• CAS NO: 119788-62-4
• Molecular Weight: 240.302
• Mol File: 119788-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R*,3S*)-2-Hydroxy-1,3-diphenyl-1-butanon(CAS DataBase Reference)
• NIST Chemistry Reference: (2R*,3S*)-2-Hydroxy-1,3-diphenyl-1-butanon(119788-62-4)
• EPA Substance Registry System: (2R*,3S*)-2-Hydroxy-1,3-diphenyl-1-butanon(119788-62-4)

Safety Data

• Hazardous Substances Data: 119788-62-4(Hazardous Substances Data)

Upstream product

• 827-36-1 2-(N,N-dimethylamino)-2-phenylacetonitrile 
• 93-53-8 (S)-2-phenyl-propionaldehyde 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 119788-48-6 (1-Methoxy-1-methylethoxy)phenylacetonitril 
• 5411-12-1 trans-(2S,3R)-epoxy-1,3-diphenylpropan-1-one 
• 75-24-1 trimethylaluminum 
• 532-28-5 (RS)-mandelonitrile 

Downstream Products

• 100-52-7 benzaldehyde 
• 93-53-8 (S)-2-phenyl-propionaldehyde 
• 243860-93-7 (1S,2R,3S)-1,2-Dihydroxy-1,3-diphenylbutane 

Relevant articles and documents

Stereocontrolled ring-opening of some enantiomerically enriched epoxy ketones and epoxy alcohols using trimethylaluminium: Synthesis of (S)-2-arylpropanoic acids

Poly-(D)-leucine-catalysed epoxidation of chalcone furnished epoxide (+)-6; treatment of this epoxide with trimethylaluminium followed by zinc borohydride reduction and oxidative cleavage furnished (S)-2-phenylpropanoic acid 11. In a complementary sequence epoxy ketones (-)-6 and 25 were converted into (S)-2-phenylpropanoic acid and (S)-fenoprofen 5 respectively by reduction with zinc borohydride, reaction with trimethylaluminium and oxidative cleavage. Similarly epoxy ketones (-)-6, 21 and 28 were treated with methylmagnesium iodide, trimethylaluminium and the resultant alcohols subjected to oxidative cleavage to afford (S)-2-phenylpropanoic acid (from the first two substrates) and (S)-naproxen 1.