1197880-07-1

Basic information

• Product Name: (E)-methyl 3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate
• Synonyms: (E)-methyl 3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate
• CAS NO: 1197880-07-1
• Molecular Weight: 335.406
• Mol File: 1197880-07-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate(1197880-07-1)
• EPA Substance Registry System: (E)-methyl 3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate(1197880-07-1)

Safety Data

• Hazardous Substances Data: 1197880-07-1(Hazardous Substances Data)

Upstream product

• 88738-86-7 methyl (E)-3-[4-(bromomethyl)phenyl]prop-2-enoate 
• 158229-19-7 2,5,7-trimethyl-3H-imidazo[4,5-b]pyridine 

Downstream Products

• 1197880-06-0 (E)-3-(4-((2,5,7-trimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol 

Relevant articles and documents

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis

GPR4, a G-protein coupled receptor, functions as a proton sensor being activated by extracellular acidic pH and has been implicated in playing a key role in acidosis associated with a variety of inflammatory conditions. An orally active GPR4 antagonist 39c was developed, starting from a high throughput screening hit 1. The compound shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain.