119817-95-7Relevant articles and documents
Lipase catalysed synthesis of optically enriched α-haloamides
Azim, Abul,Sharma, Sunil K.,Olsen, Carl E.,Parmar, Virinder S.
, p. 1345 - 1348 (2001)
An efficient lipase catalysed synthesis of optically enriched α-halogenated amides with concomitant optical enrichment of the starting α-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.
DOTMA-based amides (DOTMAMs) as a platform for the development of PARACEST MRI contrast agents
Suchy,Li,Milne,Bartha,Hudson
, p. 62647 - 62655 (2016/07/16)
A synthetic methodology leading to previously unknown DOTMA-based secondary amides (DOTMAMs) has been developed. Alkylation of cyclen with l-lactic acid-derived pseudohalides was used as a key step affording the alkyl- and aryl-decorated DOTMAMs. Amino acid-decorated DOTMAMs were obtained via peptide coupling between DOTMA and protected amino acids. Metallation of the DOTMAMs ligand with Tm3+ gave complexes exhibiting proximal amide proton based paramagnetic CEST effects at -50 ppm relative to water.
Enzymatic Aminolysis and Transamidation Reactions
Gotor, Vicente,Brieva, Rosario,Gonzalez, Carmen,Rebolledo, Francisca
, p. 9207 - 9214 (2007/10/02)
Chiral amides can be obtained from (+/-)-2-chloropropionate esters and a wide range of amines when the reaction is catalyzed by Candida cylindracea lipase.The enantioselection of the enzyme in this aminolysis reaction depends on the substrate and nucleoph
