1198271-75-8

Basic information

• Product Name: N-(2,3-dimethylphenyl)-2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide
• CAS NO: 1198271-75-8
• Molecular Weight: 405.544
• Mol File: 1198271-75-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,3-dimethylphenyl)-2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dimethylphenyl)-2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide(1198271-75-8)
• EPA Substance Registry System: N-(2,3-dimethylphenyl)-2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide(1198271-75-8)

Safety Data

• Hazardous Substances Data: 1198271-75-8(Hazardous Substances Data)

Upstream product

• 1198271-62-3 sodium 4-(naphthalen-2-yl)-1,2,3-thiadiazole-5-thiolate 
• 2564-07-0 2-chloro-N-(2, 3-dimethylphenyl)acetamide 

Relevant articles and documents

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthesized and evaluated as potent inhibitors of HIV-1. Among the newly disclosed TTAs, compounds 7f, 7g and 7c were the most potent inhibitors of HIV-1 replication of the series (EC50 = 0.17 ± 0.02, 0.36 ± 0.19 and 0.39 ± 0.05 μM, respectively), coupled with a reasonable selectivity index (SI > 1452, >845, and >774, respectively). They possess improved or similar HIV-1 inhibitory activity compared with NVP (EC50 = 0.208 μM) and DLV (EC50 = 0.320 μM). The preliminary structure-activity relationships among the newly synthesized congeners are discussed briefly and rationalized by docking studies. Crown Copyright