1198355-58-6

Basic information

• Product Name: 1-(2-fluoro-1,1-dimethoxyethyl)-3,5-dinitrobenzene
• CAS NO: 1198355-58-6
• Molecular Weight: 274.206
• Mol File: 1198355-58-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-1,1-dimethoxyethyl)-3,5-dinitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-1,1-dimethoxyethyl)-3,5-dinitrobenzene(1198355-58-6)
• EPA Substance Registry System: 1-(2-fluoro-1,1-dimethoxyethyl)-3,5-dinitrobenzene(1198355-58-6)

Safety Data

• Hazardous Substances Data: 1198355-58-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 14401-75-3 1-(3,5-dinitrophenyl)ethanone 

Relevant articles and documents

Microwave assisted fluorination: an improved method for side chain fluorination of substituted 1-arylethanones

A two-step, one-pot microwave (MW) assisted fluorination of 1-arylethanones to their corresponding 1-aryl-2-fluoroethanones has been developed. The first step utilises Selectfluor as a fluorinating agent in methanol forming 1-aryl-2-fluoroethanones and their corresponding dimethyl acetals. In the second step, water is added and Selectfluor acts as a Lewis acid in the hydrolytic cleavage of the dimethyl acetals. Compared to the thermal synthesis, the MW assisted method leads to a reduction in reaction time both in the fluorination and for the dimethyl acetal cleavage. Moreover, the one-pot procedure reduces reagent and solvent consumption. The method is best suited for the preparation of 1-aryl-2-fluoroethanones containing substituents that deactivates electrophilic aromatic substitution, however highly electron deficient ketones such as 1-(3,5-dinitrophenyl)ethanone reacts more slowly. Reactions using electron rich aromatic ketones had a low regioselectivity, and also produced fluoroaromatic products.