119878-68-1

Basic information

• Product Name: 8-phenylamino-2′-deoxyguanosine
• Synonyms: 8-phenylamino-2′-deoxyguanosine
• CAS NO: 119878-68-1
• Molecular Weight: 358.357
• Mol File: 119878-68-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 8-phenylamino-2′-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-phenylamino-2′-deoxyguanosine(119878-68-1)
• EPA Substance Registry System: 8-phenylamino-2′-deoxyguanosine(119878-68-1)

Safety Data

• Hazardous Substances Data: 119878-68-1(Hazardous Substances Data)

Upstream product

• 71825-04-2 N-(Acetoxy)anilin 
• 961-07-9 2'-Deoxyguanosine 
• 98-95-3 nitrobenzene 
• 1124321-42-1 8N-(phenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 100-65-2 N-Phenylhydroxylamine 
• 1124321-42-1 C₂₈H₄₆N₆O₄Si₂ 
• 201024-81-9 C,N-diphenylnitrone 
• 19958-58-8 N-benzoyl-N-phenyl-O-(acetyl)hydroxylamine 
• 369651-32-1 N-(Benzoyl)-N-(deoxyguanosin-8-yl)aniline 

Downstream Products

• 1125587-01-0 N₂-formamidino-8N-(phenylamino)-2'-deoxyguanosine 

Relevant articles and documents

New syntheses of DNA adducts from methylated anilines present in tobacco smoke

A new synthetic pathway for the formation of deoxyguanosine- monoarylamine adducts is described, involving the generation and use of arylnitrenes as electrophilic synthons. Photolysis of aryl azides, the most common method for generating arylnitrenes, was

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

Synthesis and characterization of model ultimate carcinogens/metabolites derived from lead tetraacetate oxidation of arylnitrones: 2′-Deoxyguanosine adducts

The synthesis of model reactive metabolites 4a-c by lead tetraacetate (LTA) oxidation of arylnitrones 3a-c is described. Compounds 4a-c react with deoxyguanosine (dG) to give N-benzoylated C8-adducts 5a-c. Following debenzoylation with the heterogeneous system (sodium carbonate/methanol) leads to the corresponding C8-adducts 6a-c.