119898-65-6

Basic information

• Product Name: Adenosine, 5'-O-[(1,1-dimethylethyl)diphenylsilyl]-
• CAS NO: 119898-65-6
• Molecular Formula: C26H31N5O4Si
• Molecular Weight: 505.649
• Mol File: 119898-65-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Adenosine, 5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(119898-65-6)
• EPA Substance Registry System: Adenosine, 5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(119898-65-6)

Safety Data

• Hazardous Substances Data: 119898-65-6(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 58-61-7 adenosine 
• 118-00-3 G 

Downstream Products

• 119898-67-8 5'-O-t-butyldiphenylsilyladenosine dialdehyde 
• 214900-47-7 Methanesulfonic acid (2R,3R,4R,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester 
• 557771-59-2 (2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-bromo-5-((tert-butyldiphenylsilyloxy)methyl)tetrahydrofuran-3-yl acetate 
• 141684-87-9 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl]adenine 
• 119898-91-8 3'-deoxy-3'-N-L-phenylalanyl-2',3'-secoadenosine 
• 119923-12-5 5'-O-t-butyldiphenylsilyl-2',3'-dideoxy-2',3'-diiodo-2',3'-secoadenosine 
• 119898-69-0 5'-O-t-butyldiphenylsilyl-2',3'-secoadenosine 
• 119898-83-8 3'-azido-5'-O-t-butyldiphenylsilyl-3'-deoxy-2',3'-secoadenosine 
• 119898-78-1 5'-O-t-butyldiphenylsilyl-3'-deoxy-3'-iodo-2'-O-mesyl-2',3'-secoadenosine 
• 119898-90-7 3'-N-(N'-benzyloxycarbonyl-L-phenylalanyl)-3'-deoxy-2',3'-secoadenosine 
• 119898-82-7 2'-O-acetyl-3'-azido-5'-O-t-butyldiphenylsilyl-3'-deoxy-2',3'-secoadenosine 
• 119898-80-5 3'-azido-5'-O-t-butyldiphenylsilyl-3'-deoxy-2'-O-mesyl-2',3'-secoadenosine 
• 119898-77-0 5'-O-t-butyldiphenylsilyl-3'-deoxy-3'-iodo-2',3'-secoadenosine 2'-(phenyl methylphosphonate) 
• 119898-73-6 5'-O-t-butyldiphenylsilyl-2',3'-di-O-mesyl-2',3'-secoadenosine 

Relevant articles and documents

Stereoselective and Divergent Aza-Adenosine and Aza-Guanosine Syntheses from Xylofuranose, the Key Fragments of a STING Cyclic Dinucleotide Agonist

The stereoselective and divergent synthesis of two aza-nucleosides is reported. Starting from xylofuranose 9, aza-adenosine 2 was prepared in 13 steps and 7% overall yield, and aza-guanosine 3 was prepared in 13 steps and 7.8% overall yield. Compared to t

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentra

Design, synthesis and anti flaviviridae activity of N6-, 5′,3′-O- and 5′,2′-O-substituted adenine nucleoside analogs

During a random screening of representative libraries of nucleoside analogues we discovered that the adenine derivatives FEVB28 and FEG118 were Flaviviridae inhibitors endowed with potency comparable, if not superior, to that of ribavirin. Those studies prompted us to design a new class of protected nucleoside analogs, reported herein, which displays interesting anti-bovine viral diarrhea virus (BVDV) activity and low cytotoxicity in cell-based assays (4, 23, 29 EC50: 14, 11, 26 μM respectively, CC50 > 100 μM) and appreciable activity in enzyme assays against the RNA dependent RNA polymerase (RdRp) of BVDV (4, 23, 29, RdRp inhibition activity 27, 16, 15 μM respectively). A molecular modeling study was also carried out to highlight the possible interactions between this compounds class and the corresponding hepatitis C virus (HCV) enzyme.