1199215-71-8

Basic information

• Product Name: carbamic acid, 1H-indol-3-yl-, 1,1-dimethylethyl ester
• Synonyms: carbamic acid, 1H-indol-3-yl-, 1,1-dimethylethyl ester;tert-butyl 1H-indol-3-ylcarbamate
• CAS NO: 1199215-71-8
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.27834
• Mol File: 1199215-71-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 350.4±15.0 °C(Predicted)
• Appearance: /
• Density: 1.216±0.06 g/cm3(Predicted)
• PKA: 14.68±0.43(Predicted)
• CAS DataBase Reference: carbamic acid, 1H-indol-3-yl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: carbamic acid, 1H-indol-3-yl-, 1,1-dimethylethyl ester(1199215-71-8)
• EPA Substance Registry System: carbamic acid, 1H-indol-3-yl-, 1,1-dimethylethyl ester(1199215-71-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1199215-71-8(Hazardous Substances Data)

Upstream product

• 7250-19-3 3-aminoindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-65-0 tert-butyl alcohol 
• 771-50-6 1H-indole-3-carboxylic acid 

Downstream Products

• 1258059-37-8 4-phenyl-2-(p-tolyl)-δ-carboline 
• 1258059-34-5 2-(4-chlorophenyl)-4-phenyl-5H-pyrido[3,2-b]indole 
• 1258059-40-3 C₂₄H₁₇ClN₂ 
• 1258059-36-7 C₂₅H₂₀N₂O 
• 1258059-38-9 C₂₃H₁₆N₂O 
• 1258059-39-0 C₂₅H₂₀N₂O₂ 
• 1258059-35-6 2-(4-bromophenyl)-4-phenyl-δ-carboline 
• 57778-93-5 1H-indol-3-amine hydrochloride 
• 1438393-73-7 ethyl 4-(4-methoxybenzoyl)-5H-pyrimido[5,4-b]indole-2-carboxylate 
• 1438393-74-8 (4-methoxyphenyl)(5H-pyrimido[5,4-b]indol-4-yl)methanone 
• 1438393-75-9 (4-hydroxyphenyl)(5H-pyrimido[5,4-b]indol-4-yl)methanone 

Relevant articles and documents

Total synthesis of 4-azaeudistomin Y1 and analogues by inverse-electron demand diels-alder reactions of 3-aminoindoles with 1,3,5-triazines

A new inverse-electron-demand Diels-Alder (IDA) reaction of 3-aminoindoles as dienophiles was developed for the efficient preparation of 4-aza-β-carbolines in high yields. Because N1-unprotected 3-aminoindoles show poor thermal stability, a one-pot protocol was developed that combines the removal of tert-butoxycarbonyl protecting groups with the IDA reaction. This protocol, using tert-butyl 1H-indol-3-ylcarbamates as reactants, gave the corresponding IDA products in excellent yields. The new IDA methodology was used in a total synthesis of 4-azaeudistomin Y1, which was obtained in 57% overall yield in four steps. Moreover, the chemistry is suitable for the rapid preparation, through either Friedel-Crafts acylation or amide-formation reactions, of analogues that are useful for exploring structure-activity relationships at the C1-position. Georg Thieme Verlag Stuttgart · New York.