119997-26-1

Basic information

• Product Name: N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine
• Synonyms: N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine
• CAS NO: 119997-26-1
• Molecular Weight: 368.594
• Mol File: 119997-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine(119997-26-1)
• EPA Substance Registry System: N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine(119997-26-1)

Safety Data

• Hazardous Substances Data: 119997-26-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 63260-82-2 ethyl 1-benzyl-4-phenylamino-4-piperidinecarboxylate 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 75-77-4 chloro-trimethyl-silane 
• 61086-04-2 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol 

Downstream Products

• 119997-28-3 N-Benzyl-4-(acetoxymethyl)-4-propananilidopiperidine 
• 119997-27-2 N-Benzyl-4-(acetoxymethyl)-4-anilinopiperidine 

Relevant articles and documents

Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines

A new class of piperidine derivatives is added to the increasing family of compounds related to fentanyl and carfentanil. Herein, we describe the synthesis and pharmacology of a number of 1-(arylethyl)-4-(acylamino)-4-[(acyloxy)-methyl]piperidines such as 9, 15, and 23. As expected, many of these congeners of fentanyl are extremely potent narcotic agonists. The aim of the study was to identify short-acting analgesic agents (i.e. less than 6 min in the mouse hot-plate assay) for possible use in the surgical theater. Many of the drugs proved to be of intermediate and long duration (i.e. 6-15 min and > 15 min, respectively). In addition to analgesic activity, many of the compounds exhibited anesthetic properties as well. The structure-activity relationship for these entities is presented and discussed.