120-35-4

Basic information

• Product Name: 3-Amino-4-methoxybenzanilide
• Synonyms: AMAN;AMBA;3-AMINO-4-METHOXYBENZANILIDE;3-AMINO-4-METHOXY-N'-PHENYL BENZAMIDE;3-AMINO-P-ANISANILIDE;LABOTEST-BB LT01138545;FAST RED KD BASE;3-Amino-p-anisanilide,prac.,95%
• CAS NO: 120-35-4
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27
• EINECS: 204-388-4
• Product Categories: Intermediates of Dyes and Pigments;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 120-35-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 154-156°C
• Boiling Point: 385.1°C (rough estimate)
• Flash Point: 174.3 °C
• Appearance: white or light yellow powder
• Density: 1.1338 (rough estimate)
• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.6419 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.44±0.70(Predicted)
• CAS DataBase Reference: 3-Amino-4-methoxybenzanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methoxybenzanilide(120-35-4)
• EPA Substance Registry System: 3-Amino-4-methoxybenzanilide(120-35-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: CV7400000
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 120-35-4(Hazardous Substances Data)

Usage

Chemical Properties

Gray powder.

Uses

Different sources of media describe the Uses of 120-35-4 differently. You can refer to the following data:
1. 3-Amino-4-methoxybenzanilide is used in preparation method of Cyanate resin-based near-zero expansion composite material truss rod.
2. Dyes, pharmaceuticals, and other organic chemicals.

InChI:InChI=1/C14H14N2O2/c1-18-13-8-7-10(9-12(13)15)14(17)16-11-5-3-2-4-6-11/h2-9H,15H2,1H3,(H,16,17)

Upstream product

• 98-88-4 benzoyl chloride 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 137-52-0 N-[2-methoxy-5-chlorophenyl]-3-hydroxy-2-naphthalene carboxamide 
• 2840-26-8 3-amino-4-methoxybenzoic acid 
• 62-53-3 aniline 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 97-32-5 3-nitro-4-methoxybenzanilide 
• 41870-24-0 (4-methoxy-3-nitrophenyl)methanol 
• 89-41-8 4-methoxy-3-nitrobenzoic acid 

Downstream Products

• 228422-87-5 4-methoxy-3-phenylamino-N-phenylbenzamide 
• 55805-64-6 C₁₄H₁₂N₃O₂⁽¹⁺⁾*Cl^(1-) 
• 169762-05-4 3-Amino-4-methoxy-4'-N,N-Di-methylaminobenzophenone 

Relevant articles and documents

Preparation method of red base KD

The invention discloses a method for producing red base KD (3-amino-4-methoxybenzanilide) from 3-nitro-4-methoxybenzoic acid. The method comprises the following steps: taking the 3-nitro-4-methoxybenzoic acid and aniline as raw materials, controlling under certain conditions for shrinkage and condensation reaction in a reactor with a jacket heat conduction oil heating function to obtain a condensate, performing reduction reaction on the condensate to obtain a red base KD coarse product, reducing the red base KD coarse product and obtaining a red base KD finished product through acid dissolution, de-coloring, filtering, neutralizing, suction filtration, rinsing and drying. The method disclosed by the invention has the advantages that the high-purity 3-nitro-4-methoxybenzoic acid is adoptedas the raw material, process conditions for reaction points are controlled, and the most appropriate process ratio is found, so that the product yield and the quality are improved. Therefore, 'three wastes' are greatly reduced, wastes, waste gas and waste water are easy to treat, the process is simpler, the operation is safer, the yield is improved greatly, the energy consumption is reduced, and ared 175 series product as a produced pigment is more bright in color; according to the method disclosed by the invention, the yield is 95 percent or higher, and the content is up to 99 percent or higher.

Synthesizing method of dye compound 3-amino-4-methoxy benzanilide

The invention relates to a synthesizing method of a dye compound 3-amino-4-methoxy benzanilide. The synthesizing method includes the steps of S1, in organic solvent and in the presence of composite catalyst, oxidizing agent and organic ligand, allowing a compound as shown in formula (I) and a compound as shown in formula (II) to react with each other; S2, directly adding reducing agent to perform reduction reaction after the reaction of the step S1, and performing post-treatment to obtain the 3-amino-4-methoxy benzanilide. The synthesizing method has the advantages that by using an appropriate reaction substrate and the comprehensive selection and coordination of the catalyst, the oxidizing agent, the organic ligand and the organic solvent, the 3-amino-4-methoxy benzanilide can be synthesized in a high-yield manner; in addition, the reaction flow is shortened, and the method is promising in application prospect and good in production potential.

Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors

The influenza virus is a persistent cause of mortality and morbidity on an annual basis and thus presents itself as an important target for pharmaceutical investigation. In this work, substituted bisaryl amide compounds were found to be a new class of potential anti-influenza agents, and a series of substituted bisaryl amide compounds were synthesised and evaluated for their anti-influenza virus activities. The analysis of the results produced a preliminary structure-activity relationship study (SAR). Compounds 1a, 1g, 1h, 1j, 1l and 1n exhibited clear antiviral activities against the influenza A (A/Guangdong Luohu/219/2006, H1N1) virus with 50% inhibitory concentrations (IC50) for virus growth ranging from 12.5 to 59.0 μM. Specifically, compound 1j also possessed antiviral activity against both oseltamivir-resistant influenza (A/Jinnan/15/2009) virus and influenza B (B/Jifang/13/97) virus with IC 50 values of 9.2 μM and 21.4 μM, respectively. Compound 1j is thus worth further investigation as an anti-influenza virus candidate.