120060-93-7

Basic information

• Product Name: methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetate
• Synonyms: methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetate
• CAS NO: 120060-93-7
• Molecular Weight: 387.435
• Mol File: 120060-93-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetate(120060-93-7)
• EPA Substance Registry System: methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetate(120060-93-7)

Safety Data

• Hazardous Substances Data: 120060-93-7(Hazardous Substances Data)

Upstream product

• 22979-35-7 Methyl phenyldiazoacetate 
• 84418-43-9 9-fluorenylmethyl carbamate 
• 67-56-1 methanol 
• 163883-97-4 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-phenylacetic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 2835-06-5 phenylglycin 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 

Downstream Products

• 4425-82-5 9-methylene-fluorene 
• 24461-61-8 phenylglycine methyl ester 

Relevant articles and documents

Formation of Non-Natural α,α-Disubstituted Amino Esters via Catalytic Michael Addition

The enolate monoanion of amino esters is explored, and the first catalytic Michael addition of α-amino esters is demonstrated. These studies indicate that the acidity of the αC-H is the primary factor determining reactivity. Thus, polyfluorophenylglycine amino esters yield novel α-amino esters in the presence of a catalytic amount of a guanidine-derived base and Michael acceptors. Reactivity requires an acidic N-H, which is accomplished using common protecting groups such as N-Bz, N-Boc, and N-Cbz. Calculations and labeling experiments provide insight into the governing principles in which a key C-to-N proton transfer occurs, resulting in an expansion of the scope to include a number of natural amino esters. The study culminates with a late-stage functionalization of peptidic γ-secretase inhibitor, DAPT.

Determination of Chemical and Enantiomeric Purity of α-Amino Acids and their Methyl Esters as N-Fluorenylmethoxycarbonyl Derivatives Using Amylose-derived Chiral Stationary Phases

Liquid chromatographic enantiomer separation and simultaneous determination of chemical and enantiomeric purity of α-amino acids and their methyl esters as N-fluorenylmethoxycarbonyl (FMOC) derivatives was performed on three covalently bonded type chiral stationary phases (CSPs) derived from amylose derivatives. The enantiomer separation of α-amino acid esters as N-FMOC derivatives was better than that of the corresponding acids, especially for CSP 1 and 2. Chemical impurities as the corresponding racemic acids present in several commercially available racemic amino acid methyl esters were observed to be 0.49–17.50%. Enantiomeric impurities of several commercially available L-amino acid methyl esters were found to be 0.03–0.58%, whereas chemical impurities as the corresponding racemic acids present in the same analytes were found to be 0.13–13.62%. This developed analytical method will be useful for the determination of chemical and enantiomeric purity of α-amino acids and/or esters as N-FMOC derivatives using amylose-derived CSPs.