1201807-92-2Relevant articles and documents
Hydrogels generated by low-molecular-weight PEGylated luteolin and α-cyclodextrin through self-assembly for 5-fluorouracil delivery
Qing, Weixia,Wang, Yong,Li, Huan,Zhu, Jinhua,Liu, Xiuhua
, p. 95812 - 95817 (2016)
Hydrophobic luteolin (LUT) was conjugated to the oligomeric chain of methoxypoly(ethylene glycol) (mPEG) to form novel amphiphilic mPEG1900-LUT conjugates. Then mPEG1900-LUT, by using its adjacent 3′ and 4′ hydroxyl groups, were asse
Discovery and synthesis of novel luteolin derivatives as DAT agonists
Zhang, Jiange,Liu, Xianbo,Lei, Xinsheng,Wang, Lei,Guo, Lihe,Zhao, Gang,Lin, Guoqiang
experimental part, p. 7842 - 7848 (2011/01/13)
Luteolin, 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one, has been proposed and proved to be a novel dopamine transporter (DAT) activator. In order to develop this potential of luteolin, a series of novel luteolin derivatives were designed, synthesized, and evaluated for their DAT agonistic activities, utilizing constructed Chinese hamster ovary (CHO) cell lines stably expressing rat DAT. Biological screening results demonstrated that luteolin derivatives 1d, 1e, and 4c carry great DAT agonistic potency (EC50 = 0.046, 0.869, and 1.375 μM, respectively) compared with luteolin 8 (EC50 = 1.45 ± 0.29 μM). Luteolin derivative 1d, notably, exhibited a 32-fold-higher DAT agonistic potency than luteolin. These luteolin derivatives represent a novel DAT agonist class, from which lead compounds useful for exploration of additional novel DAT agonists could be drawn.