1201808-21-0

Basic information

• Product Name: 7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one
• Synonyms: 3,4-DiphenylMethylidene Luteolin;7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one
• CAS NO: 1201808-21-0
• Molecular Formula: C₂₈H₁₈O₆
• Molecular Weight: 450.43892
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1201808-21-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chlorofrom (Slightly, Heated), DMSO (Slightly)
• CAS DataBase Reference: 7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one(1201808-21-0)
• EPA Substance Registry System: 7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one(1201808-21-0)

Safety Data

• Hazardous Substances Data: 1201808-21-0(Hazardous Substances Data)

Usage

Description

7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one is a Luteolin (L475000) derivative, characterized by its light yellow powder form. 7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one is known for its potential applications in the development of DAT agonists, specifically as Luteolin derivatives.

Uses

Used in Pharmaceutical Industry:
7-Dihydroxy-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5-4H-1-benzopyran-4-one is used as a key component in the preparation of DAT agonists Luteolin derivatives. These agonists are crucial in the development of pharmaceuticals targeting the dopamine transporter, playing a significant role in the treatment of various neurological and psychiatric disorders.

Upstream product

• 2051-90-3 Dichlorodiphenylmethane 
• 491-70-3 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on 

Downstream Products

• 1201808-18-5 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-4-oxo-4H-chromen-7-yl propionate 
• 1201808-23-2 5,7-bis(benzyloxy)-2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one 
• 1201808-13-0 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-7-ethoxy-5-hydroxy-4H-chromen-4-one 
• 1201808-20-9 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-4-oxo-4H-chromen-7-yl isobutyrate 
• 1201808-19-6 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-4-oxo-4H-chromen-7-yl butyrate 
• 1201808-16-3 C₃₃H₂₈O₆ 
• 1201808-22-1 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dimethoxy-4H-chromen-4-one 
• 1201808-17-4 C₃₂H₂₆O₆ 
• 1201808-15-2 C₃₂H₂₆O₆ 
• 1201808-14-1 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-7-isopropoxy-4H-chromen-4-one 
• 1443679-17-1 O₇-nitrooxyethyl-O₃',O₄'-diphenylmethane luteolin 
• 1443679-18-2 C₃₂H₂₅NO₉ 
• 1443679-19-3 C₃₄H₂₉NO₉ 
• 1443679-20-6 O₇-nitrooxyethyl luteolin 

Relevant articles and documents

A Practical and Efficient Conversion of Luteolin into Luteoloside

A new practical and efficient preparation of the flavonoid luteoloside is reported in an excellent overall yield of 40% via a four-step synthetic approach.

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

Two β-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-NMR technique. Some of these conjugates also exhibited selective BACE1 inhibition over other aspartyl proteases such as BACE-2 and renin, as well as poor cytotoxicity. Taken together, conjugates 4 represent a new series of BACE inhibitors warrants further investigation for their potential in Alzheimier's disease therapy.

Preparation of flavone derivative and application to neuraminidase inhibition

The invention relates to a heteroaromatic carboxylate flavone derivative, a preparation method and application thereof. The heteroaromatic carboxylate flavone derivative has a structural formula shown as formula (I), wherein R1 and R4 are respectively hydrogen, acetyl or heteroaromatic acyl; R2 and R3 are hydroxyl or acetic ester group respectively; R5 is hydrogen, hydroxyl, or acetic ester group respectively, and the derivative is 7-heteroaromatic carboxylate flavone derivative, 4'-heteroaromatic carboxylate flavone derivative or 7, 4'-heteroaromatic carboxylate flavone derivative. The invention also relates to the preparation method and application of the heteroaromatic carboxylate flavone derivative. The heteroaromatic carboxylate flavone derivative provided by the invention can inhibit the activity of neuraminidase, and has inhibitory activity higher than that of natural flavones to some compounds, thus being applicable to preparation of drugs preventing and treating viral cold. (formula (I)).