1201913-74-7Relevant articles and documents
Synthesis of Tofogliflozin as an SGLT2 Inhibitor via Construction of Dihydroisobenzofuran by Intramolecular [4 + 2] Cycloaddition
Murakata, Masatoshi,Kawase, Akira,Kimura, Nobuaki,Ikeda, Takuma,Nagase, Masahiro,Koizumi, Masatoshi,Kuwata, Kazuaki,Maeda, Kenji,Shimizu, Hitoshi
, p. 548 - 557 (2019)
The synthesis of tofogliflozin (1), a sodium glucose cotransporter 2 (SGLT2) inhibitor, was achieved through the key steps of intramolecular [4 + 2] cycloaddition of dienone-yne intermediate, aerobic aromatization, and anomeric equilibration, thus enablin