120241-79-4

Basic information

• Product Name: Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)
• Synonyms: Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI);3-(1H-1,2,3-triazol-4-yl)pyridine;3-TYP
• CAS NO: 120241-79-4
• Molecular Formula: C₇H₆N₄
• Molecular Weight: 146.14934
• Product Categories: PYRIDINE;API
• Mol File: 120241-79-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 180-182 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
• Boiling Point: 386.6±17.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.54±0.70(Predicted)
• CAS DataBase Reference: Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)(120241-79-4)
• EPA Substance Registry System: Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)(120241-79-4)

Safety Data

• Hazardous Substances Data: 120241-79-4(Hazardous Substances Data)

Usage

Description

Pyridine, 3-(1H-1,2,3-triazol-4-yl)(9CI) is an organic compound that features a pyridine ring with a 1,2,3-triazole group attached to it. This chemical structure endows it with unique properties and makes it a valuable building block in the synthesis of various biologically active molecules.

Uses

Used in Pharmaceutical Industry:
Pyridine, 3-(1H-1,2,3-triazol-4-yl)(9CI) is used as a reactant for the synthesis of 4-aryl-1H-1,2,3-triazoles, which are known for their enhanced Indoleamine 2,3-dioxygenase (IDO) inhibitory potency compared to the conventional 1-methyltryptophan. This application is particularly relevant in the development of new drugs targeting IDO, an enzyme overexpressed in various cancers and immune disorders, making it a promising therapeutic target.

Upstream product

• 2510-23-8 3-Ethynylpyridine 
• 500-22-1 3-pyridinecarboxaldehyde 
• 75-52-5 nitromethane 
• 22568-11-2 3-(2-nitroethenyl)pyridine 
• 63671-82-9 3-(2,2-dibromovinyl)pyridine 
• 4648-54-8 trimethylsilylazide 
• 45988-16-7 C₆H₆NO₄S^(1-)*Na⁽¹⁺⁾ 
• 453523-36-9 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide 

Downstream Products

• 159792-72-0 4-(1-benzyl-3-piperidyl)-2-(methoxymethyl)-1,2,3-triazole 
• 1337917-13-1 4-(4-pyridin-3-yl-[1,2,3]triazol-2-yl)-benzoic acid ethyl ester 
• 1337917-12-0 3-(2-(3,5-dimethoxyphenyl)-2H-1,2,3-triazol-4-yl)pyridine 

Relevant articles and documents

Two new mononuclear zinc(II) and cadmium(II) coordination polymers based on 4-(3-pyridyl)-2H-1,2,3-triazole: Syntheses, structures, theoretical and fluorescent properties

Two new d10 metal coordination polymers (CPs), [Zn(L)NO3]n (1) and [Cd(L)I2]n (2) (L = 4-(3-Pyridyl)-2H-1,2,3-triazole), have been designed and synthesized from ZnII/CdII ions and the rigid L ligand. The CPs 1 and 2 have been structurally characterized by single-crystal X-ray diffraction analyses, elemental analysis, IR spectroscopy, powder X-ray diffraction (PXRD) and thermal gravimetric analyses (TGA). CP 1 exhibits a hcb (3,3)-connected 2D network with the point symbol (63) and further forms a supramolecular 3D structure via hydrogen bonds. CP 2 reveals a 1D straight chain constructed by units of [Cd(1)N2I4] and hydrogen bonding leads to the formation of supramolecular 3D system. In addition, time-dependent density functional theory calculations with B3LYP functional were performed on L, CPs 1 and 2 to rationalize their experimental absorption spectra. The luminescence properties of L, CPs 1 and 2 in solid-state and different solvents have been also investigated.

The synthesis of 1,2,3-triazoles from nitroalkenes - Revisited

Nitroalkenes or vicinal acetoxy nitro derivatives undergo a clean reaction with sodium azide in hot dimethyl sulfoxide to give the corresponding 1,2,3-triazoles in good yield. Georg Thieme Verlag Stuttgart.

Synthesis method of NH-1,2,3-triazole compound

The invention relates to a synthesis method of a NH-1,2,3-triazole compound. The synthesis method is characterized by comprising the following steps that aldehyde, a nitro compound, sodium azide, a solvent and an additive react for 1-8 hours through a one-pot method at the temperature of 80 DEG C to 150 DEG C, and after reacting is finished, NH-1,2,3-triazole can be prepared through aftertreatment. According to the synthesis method, aldehyde, the nitro compound and sodium azide which are cheap and easy to obtain are adopted as raw materials, and the NH-1,2,3-triazole compound can be conveniently prepared from the three components. Compared with an existing method, the method has the advantages that the raw materials are low in cost, simple and easy to obtain, operation is easy and convenient, and the reaction efficiency is high.

Synthetic method of NH-1,2,3-triazole bipyridine compounds

The invention relates to a novel synthetic method of NH-1,2,3-triazole bipyridine compounds. According to the methods, pyridinecarboxaldehyde, nitroalkane, sodium azide and a catalyst are sequentially added to a reaction solvent in a reaction container, the materials are stirred in the air under a heating condition and react, and the NH-1,2,3-triazole bipyridine compounds are prepared. The method has the benefits as follows: cheap and available AlCl3 is taken as the catalyst, aromatic aldehyde, nitroalkane and sodium azide have a one-pot reaction, the reaction conditions are mild, the yield is high, the raw materials are available, and the NH-1,2,3-triazole bipyridine compounds are synthesized conveniently and effectively.