120258-27-7 Usage
Description
4-Bromo-2-ethylthiazole is an organic compound that features a thiazole ring with a bromine atom at the 4-position and an ethyl group at the 2-position. This chemical structure endows it with unique properties that make it a valuable intermediate in the synthesis of various pharmaceuticals and organic compounds.
Uses
Used in Pharmaceutical Industry:
4-Bromo-2-ethylthiazole is used as a key intermediate in the synthesis of epothilone E analogs, which are important microtubule-stabilizing agents with potential applications in cancer therapy. The Stille coupling reaction, a type of cross-coupling reaction in organic chemistry, is employed to incorporate this compound into the target molecule, facilitating the development of new and effective anticancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 120258-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 120258-27:
(8*1)+(7*2)+(6*0)+(5*2)+(4*5)+(3*8)+(2*2)+(1*7)=87
87 % 10 = 7
So 120258-27-7 is a valid CAS Registry Number.
120258-27-7Relevant articles and documents
Epothilone analogs
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, (2008/06/13)
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.