120267-95-0

Basic information

• Product Name: 11-Oxa-2,4,9-triazatridec-2-enoic acid, 8-carboxy-12,12-dimethyl-10-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester, (8S)-
• CAS NO: 120267-95-0
• Molecular Formula: C27H34N4O8
• Molecular Weight: 542.589
• Mol File: 120267-95-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 11-Oxa-2,4,9-triazatridec-2-enoic acid, 8-carboxy-12,12-dimethyl-10-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester, (8S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 11-Oxa-2,4,9-triazatridec-2-enoic acid, 8-carboxy-12,12-dimethyl-10-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester, (8S)-(120267-95-0)
• EPA Substance Registry System: 11-Oxa-2,4,9-triazatridec-2-enoic acid, 8-carboxy-12,12-dimethyl-10-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester, (8S)-(120267-95-0)

Safety Data

• Hazardous Substances Data: 120267-95-0(Hazardous Substances Data)

Upstream product

• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 501-53-1 benzyl chloroformate 
• 21887-64-9 N₂-(tert-butoxycarbonyl)-L-ornithine 
• 207857-19-0 N,N'-bis(benzyloxycarbonyl)-N''-trifluoromethane-sulfonylguanidine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 

Downstream Products

• 1021879-32-2 C₃₉H₄₅N₅O₇ 
• 121785-71-5 argatroban 
• 121785-72-6 (21R)-argatroban 
• 74863-84-6 argatroban 

Relevant articles and documents

Divergent Synthesis of Aeruginosins Based on a C(sp3)￡H Activation Strategy

A general and scalable access to the aeruginosin family of marine natural products, exhibiting potent inhibitory activity against serine proteases, is reported. This was enabled by the strategic use of two recently implemented Pd-catalyzed C(sp3)￡H activation reactions. The first method allowed us to obtain the common 2-carboxy-6-hydroxyoctahydroindole (Choi) core of the target molecules on a large scale, whereas the second method provided a rapid and divergent access to various hydroxyphenyllactic (Hpla) subunits, including halogenated ones. This unique strategy, together with an optimization of the fragment coupling sequence allowed the synthesis of four aeruginosins, that is, 98A-C and 298A from the chiral pool. Among them, aeruginosin 298A was synthesized on an unprecedentedly large scale. In addition, halogenated aeruginosins 98A and 98C were synthesized for the first time, thanks to a fine-tuning of the final hydrogenation step. Go natural! A general and scalable access to the aeruginosin family of marine natural products (see graphic), exhibiting potent inhibitory activity against serine proteases, is described. The strategic use of two different Pd-catalyzed C(sp3)￡H activation reactions led to the synthesis of aeruginosins98A-C and 298A.

Synthesis of a proposed antigenic hexapeptide from Escherichia coli K88 protein fimbriae.

The hexapeptide Boc-Asp-Asp-Tyr-Arg-Gln-Lys-OMe is assembled by stepwise synthesis in solution with an overall yield of 44%. N alpha-boc-amino acids, protected with benzyl or benzyloxycarbonyl groups in the side-chains, are coupled as active estes of 1-hydroxybenzotriazole in mixtures of dichloromethane and N,N-dimethylformamide. N alpha-deprotection is accomplished with trifluoroacetic acid. Finally, hydrogenation with palladium on charcoal and ammonium formate produces the pure hexapeptide. A new one-pot synthesis of Boc-Arg(Z2) is described, and the use of this derivative in peptide coupling is studied. The synthetic peptide was coupled to BSA and used in direct immunication of rabbits.