120277-69-2

Basic information

• Product Name: 3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride
• Synonyms: Pyridine, 3-bromo-5-(chloromethyl)- (9CI);3-bromo-5-(chloromethyl)pyridine
• CAS NO: 120277-69-2
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.4676
• EINECS: -0
• Product Categories: PYRIDINE;Methyl Halides;Pyridines;Methyl Halides
• Mol File: 120277-69-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 264.965ºC at 760 mmHg
• Flash Point: 114.047ºC
• Appearance: Off-white/Solid
• Density: 1.632g/cm3
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.10±0.20(Predicted)
• CAS DataBase Reference: 3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride(120277-69-2)
• EPA Substance Registry System: 3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride(120277-69-2)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 22-26-36/37/39-45
• HazardClass: 8
• Hazardous Substances Data: 120277-69-2(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(Chloromethyl)pyridine Hydrochloride is a specialized chemical compound often used in fields such as organic chemistry and pharmaceutical research. The compound features a pyridine ring, which is a basic aromatic heterocyclic compound similar to benzene, but containing one nitrogen atom. It is brominated and has a chloromethyl group attached to the pyridine ring. Due to these specific structural properties, 3-Bromo-5-(Chloromethyl)pyridine Hydrochloride is often used as a reagent in the synthesis of various pharmaceutical and biologically active compounds. Care must be taken in its handling, as it can cause burns and serious eye damage due to its corrosive nature.

InChI:InChI=1/C6H5BrClN/c7-6-1-5(2-8)3-9-4-6/h1,3-4H,2H2

Upstream product

• 37669-64-0 (5-bromopyridin-3-yl)methanol 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 113118-81-3 5-bromopyridine-3-carbaldehyde 

Downstream Products

• 120276-48-4 3-bromo-5-(iodomethyl)pyridine 
• 258870-49-4 (2S,3R)-3-{(S)-1-[5-(4-Methoxy-phenyl)-pyridin-3-ylmethyl]-2-oxo-azepan-3-ylcarbamoyl}-5-methyl-2-propyl-hexanoic acid tert-butyl ester 
• 258870-50-7 (2S,3R)-3-{(S)-1-[5-(3-Chloro-4-fluoro-phenyl)-pyridin-3-ylmethyl]-2-oxo-azepan-3-ylcarbamoyl}-5-methyl-2-propyl-hexanoic acid tert-butyl ester 
• 39891-08-2 (5-bromo-pyridin-3-yl)-acetonitrile 
• 1272355-08-4 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)acetonitrile 
• 1272355-11-9 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)acetamide 
• 1272357-13-7 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile 
• 1272357-14-8 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanoic acid 
• 1272355-30-2 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanamide 
• 1272357-15-9 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanamide 
• 1272357-16-0 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanamide 
• 1272355-37-9 1-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)cyclopropanecarbonitrile 
• 135124-70-8 (5-bromo-3-pyridinyl)methylamine 

Relevant articles and documents

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into a series of potent and selective 3-pyridyl isoindolin-1-ones CYP11B2 inhibitors. Our systematic structure-activity relationship study enabled us to identify unique structural features that result in high selectivity against the closely homologous cortisol synthase (CYP11B1). We evaluated advanced lead molecules, exemplified by compound 52, in an in vivo cynomolgus monkey acute adrenocorticotropic hormone (ACTH) challenge model and demonstrated a superior 100-fold in vivo selectivity against CYP11B1.

DIHYDROQUINOLINE-2-ONE DERIVATIVES FOR USE AS ALDOSTERONE SYNTHASE INHIBITORS

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10 and R11 are as described herein, compositions including the compounds and methods of using the compounds.

NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as