120279-20-1

Basic information

• Product Name: 3-(2-THIENYLTHIO)BUTANOIC ACID
• Synonyms: 3-(2-THIENYLTHIO)BUTANOIC ACID;3-(2-Thienylthio)butyric acid
• CAS NO: 120279-20-1
• Molecular Formula: C₈H₁₀O₂S₂
• Molecular Weight: 202.29
• Mol File: 120279-20-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 168 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.25±0.10(Predicted)
• CAS DataBase Reference: 3-(2-THIENYLTHIO)BUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-THIENYLTHIO)BUTANOIC ACID(120279-20-1)
• EPA Substance Registry System: 3-(2-THIENYLTHIO)BUTANOIC ACID(120279-20-1)

Safety Data

• Hazardous Substances Data: 120279-20-1(Hazardous Substances Data)

Usage

General Description

3-(2-Thienylthio)butanoic acid is a chemical compound consisting of a butanoic acid molecule with a thienylthio moiety attached to the third carbon atom. It is a sulfur-containing compound that is often used in organic synthesis and pharmaceutical research. The thienylthio group gives the compound unique properties and potential biological activity. It can be used as a building block in the synthesis of various organic compounds and may have potential applications in drug development and medicinal chemistry. Its structure and properties make it an interesting target for further study in the field of organic and pharmaceutical chemistry.

Upstream product

• 107-93-7 (E)-but-2-enoic acid 
• 7774-74-5 Thiophene-2-thiol 

Downstream Products

• 120279-85-8 5,6-Dihydro-4H-6-methylthieno[2,3-b]thiopyran-4-one 
• 1197375-23-7 D-(+)-methylbenzylamine (3S)-3-(2-thienylthio)butyrate salt 

Relevant articles and documents

PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE

The present invention relates to an improved process for the preparation of (4S,6S)-4- (ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide hydrochloride ("Dorzolamide hydrochloride") having formula 1. Dorzolamide hydrochloride is prepared by the process of the present invention with high chemical and diastereomeric purity. The present invention also relates to novel intermediate of the formula 20 and a process for its preparation. Dorzolamide hydrochloride is useful in the treatment of ocular hypertension by inhibiting carbonic anhydrase enzyme.

Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI

The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzyme

Process for preparing carboxylic acid derivative

There is described a process for preparing 3-(2-thienylthio)butyric acid by converting a compound having the formula (III): STR1 wherein R is a straight chain or branched C 1 to C 4 alkyl group, whereby the production of 3-(3-thienylthio)butyric acid as a by-product which is the position isomer can be controlled to at most 0.1 mol %. 3-(2-Thienylthio)butyric acid is a useful compound as an intermediate for a medicinal compound.