120279-37-0

Basic information

• Product Name: rac-cis Dorzolamide
• Synonyms: cis-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride;Dorzolamide Related Compound B (15 mg) ((4R,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride);Dorzolamide EP Impurity B;rac-cis Dorzolamide;(4R,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide:hydrochloride;(4RS,6SR)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2, 3-b]thiopyran-2-sulfonamide 7,7-dioxide HCl;Dorzolamide Hydrochloride impurity B
• CAS NO: 120279-37-0
• Molecular Formula: C10H17ClN2O4S3
• Molecular Weight: 360.90098
• Product Categories: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 120279-37-0.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: rac-cis Dorzolamide(CAS DataBase Reference)
• NIST Chemistry Reference: rac-cis Dorzolamide(120279-37-0)
• EPA Substance Registry System: rac-cis Dorzolamide(120279-37-0)

Safety Data

• Hazardous Substances Data: 120279-37-0(Hazardous Substances Data)

Usage

Description

rac-cis Dorzolamide, also known as Dorzolamide EP Impurity B, is an impurity of Dorzolamide (D535100). It is an off-white solid with unique chemical properties.

Uses

Used in Pharmaceutical Industry:
rac-cis Dorzolamide is used as an impurity in the production of Dorzolamide, a medication used to treat glaucoma and ocular hypertension. Its presence in the manufacturing process is essential for ensuring the quality and efficacy of the final product.

Upstream product

• 120279-96-1 dorzolamide 
• 1227941-29-8 (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide di-p-toluyl-L-tartate salt 
• 154802-22-9 5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide 
• 935289-26-2 6-methyl-4-oxo-5,6-dihydro-4H-thieno[2.3-b]thiopyran-2-sulfonamide-7,7-dioxide 
• 1383784-43-7 (6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one-2-sulfonamide 
• 154716-03-7 (6S)-4-oxo-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide 
• 154802-22-9 cis-(6S)-4-hydroxy-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide 
• 147200-03-1 (4S,6S)?4?acetamido?5,6?dihydro?6?methyl?4H?thieno[2,3?b]thiopyran?2?sulfonamide?7,7?dioxide 
• 147086-79-1 (S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one 
• 1083006-59-0 (S)-6-methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonyl chloride 
• 120279-96-1 dorzolamid 
• 1310-73-2 sodium hydroxide 

Relevant articles and documents

Method for preparing dorzolamide hydrochloride and method for purifying intermediate

The invention relates to a method for preparing dorzolamide hydrochloride and a method for purifying an intermediate. The method for preparing the dorzolamide hydrochloride comprises the following steps: carrying out crystallization treatment on an ester solution of a compound ((4S, 6R-trans)-4-ethylamino-5, 6-dihydro-6-methyl-4H-thieno [2, 3-b] thiapyran-2-sulfonamide-7, 7-dioxide) as shown in the formula D15 of an intermediate to obtain a purified compound as shown in the formula D15; and reacting the compound as shown in the formula D15 with hydrochloric acid to obtain the dorzolamide hydrochloride. The synthesis process is shortened, so that the production time is saved, the efficiency is improved, and the cost is reduced.

PROCESS FOR THE PREPARATION OF DORAOLZMIDE HYDROCHLORIDE

The present invention discloses an improved process for the preparation of dorzolamide hydrochloride the compound of Formula I.

PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED OXAMIDES

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).