1202854-85-0Relevant articles and documents
6″-Azido-6″-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate
Mayer, Alain,Gloster, Tracey M.,Chou, Wayne K.,Vocadlo, David J.,Tanner, Martin E.
, p. 1199 - 1201 (2011)
6″-Azido-6″-deoxy-UDP-N-acetylglucosamine (UDP-6Az-GlcNAc) is a potential alternate substrate for N-acetylglucosaminyltransferases. This compound could be used to generate various glycoconjugates bearing an azide functionality that could in turn be subjected to further modification using Staudinger ligation or Huisgen cycloaddition. UDP-6Az-GlcNAc is synthesized from α-benzyl-N-acetylglucosaminoside in seven-steps with an overall yield of 6%. It is demonstrated to serve as a substrate donor for the glycosyl transfer reaction catalyzed by the human UDP-GlcNAc:polypeptidyltransferase (OGT) to the acceptor protein nucleoporin 62 (nup62).