1202878-17-8Relevant articles and documents
Sonogashira reactions with propyne: Facile synthesis of 4-Hydroxy-2-methylbenzofurans from Iodoresorcinols
Berliner, Martin A.,Cordi, Eric M.,Dunetz, Joshua R.,Price, Kristin E.
experimental part, p. 180 - 187 (2010/04/28)
The Sonogashira reaction of terminal alkynes and ortho-halophe- nols with subsequent cyclization is a well-precedented method for the synthesis of substituted benzofurans. Here we describe the extension of this method to the coupling of 2-iodoresorcinols and terminal alkynes, including propyne, to give 4-hydroxy-2-substi- tuted benzofurans. In particular, we describe the screening, method development, and scaleup of the reaction with propyne using standard hydrogenation equipment.
