120289-15-8

Basic information

• Product Name: 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine
• Synonyms: 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine
• CAS NO: 120289-15-8
• Molecular Weight: 420.853
• Mol File: 120289-15-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine(120289-15-8)
• EPA Substance Registry System: 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine(120289-15-8)

Safety Data

• Hazardous Substances Data: 120289-15-8(Hazardous Substances Data)

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 88150-46-3 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 120300-97-2 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methylpyridine 
• 113994-36-8 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methylpyridine 
• 120300-95-0 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine 

Relevant articles and documents

Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry

Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.