1203590-25-3

Basic information

• Product Name: 3-biphenyl-2-yl-4-hydroxy-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 1203590-25-3
• Molecular Weight: 354.449
• Mol File: 1203590-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-biphenyl-2-yl-4-hydroxy-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-biphenyl-2-yl-4-hydroxy-piperazine-1-carboxylic acid tert-butyl ester(1203590-25-3)
• EPA Substance Registry System: 3-biphenyl-2-yl-4-hydroxy-piperazine-1-carboxylic acid tert-butyl ester(1203590-25-3)

Safety Data

• Hazardous Substances Data: 1203590-25-3(Hazardous Substances Data)

Upstream product

• 2423-65-6 Pyrazin-N-Oxid(PyzNO) 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Complete regioselective addition of grignard reagents to pyrazine N-oxides, toward an efficient enantioselective synthesis of substituted piperazines

(Figure presented) A conceptually new one-pot strategy for the synthesis of protected substituted piperazines via the addition of Grignard reagents to pyrazine N-oxides is presented. This strategy is high yielding (33-91% over three steps), step-efficient, and fast. The synthesized N,N-diprotected piperazines are convenient to handle and allow for orthogonal deprotection at either nitrogen for selective transformations. In addition, this Is a synthetic route to enantiomerically enriched piperazines by using a combination of phenyl magnesium chloride and (-)-sparteine, which resulted In enantiomeric excesses up to 83%.