120361-25-3

Basic information

• Product Name: 3-thiophenecarboxaldehyde 2,4,6-triisopropylbenzenesulfonyl hydrazone
• Synonyms: 3-thiophenecarboxaldehyde 2,4,6-triisopropylbenzenesulfonyl hydrazone
• CAS NO: 120361-25-3
• Molecular Weight: 392.587
• Mol File: 120361-25-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-thiophenecarboxaldehyde 2,4,6-triisopropylbenzenesulfonyl hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-thiophenecarboxaldehyde 2,4,6-triisopropylbenzenesulfonyl hydrazone(120361-25-3)
• EPA Substance Registry System: 3-thiophenecarboxaldehyde 2,4,6-triisopropylbenzenesulfonyl hydrazone(120361-25-3)

Safety Data

• Hazardous Substances Data: 120361-25-3(Hazardous Substances Data)

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 39085-59-1 trisylhydrazine 

Relevant articles and documents

Asymmetric Radical Process for General Synthesis of Chiral Heteroaryl Cyclopropanes

A highly efficient catalytic method has been developed for asymmetric radical cyclopropanation of alkenes with in situ-generated α-heteroaryldiazomethanes via Co(II)-based metalloradical catalysis (MRC). Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to α-pyridyl and other α-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates. This new catalytic methodology provides a general access to valuable chiral heteroaryl cyclopropanes in high yields with excellent both diastereoselectivities and enantioselectivities. Combined computational and experimental studies further support the underlying stepwise radical mechanism of the Co(II)-based olefin cyclopropanation involving α- and γ-metalloalkyl radicals as the key intermediates.