1204-37-1

Basic information

• Product Name: 6,8-Dihydroxy-3-methyl-1H-2-benzopyran-1-one
• Synonyms: 6,8-Dihydroxy-3-methyl-1H-2-benzopyran-1-one;6,8-Dihydroxy-3-methylisocoumarin
• CAS NO: 1204-37-1
• Molecular Formula: C10H8O4
• Molecular Weight: 192.17
• Mol File: 1204-37-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,8-Dihydroxy-3-methyl-1H-2-benzopyran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-Dihydroxy-3-methyl-1H-2-benzopyran-1-one(1204-37-1)
• EPA Substance Registry System: 6,8-Dihydroxy-3-methyl-1H-2-benzopyran-1-one(1204-37-1)

Safety Data

• Hazardous Substances Data: 1204-37-1(Hazardous Substances Data)

Upstream product

• 151445-99-7 6,8-diacetoxy-3-methylisocoumarin 
• 1206-69-5 2-carboxy-3,5-dihydroxybenzylmethyl ketone 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 53279-32-6 2,4-dihydroxy-6-pyruvoyl-benzoic acid 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 
• 6512-31-8 2,4-dimethoxy-6-(2-oxopropyl)benzoic acid 
• 61227-52-9 5,7-dimethoxy-2-methylindan-1-one 
• 61227-55-2 4,6-dimethoxy-2-methylinden-3-yl trifluoroacetate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 122333-94-2 3-(3,5-dimethoxyphenyl)-2-methylpropanoic acid 
• 122333-93-1 3-(3,5-dimethoxyphenyl)-2-methylpropenoic acid 
• 1160239-13-3 C₁₇H₂₀O₉ 

Downstream Products

• 1702-86-9 8-hydroxy-6-methoxy-3-methylisocoumarin 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 

Relevant articles and documents

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Inhibition of Plasmodium falciparum Lysyl-tRNA Synthetase via a Piperidine-Ring Scaffold Inspired Cladosporin Analogues

Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) represents a promising therapeutic anti-malarial target. Cladosporin was identified as a selective and potent PfKRS inhibitor but lacks metabolic stability. Here, we report chemical synthesis, biological evaluation and structural characterization of analogues where the tetrahydropyran (THP) frame of cladosporin is replaced with the piperidine ring bearing functional group variations. Thermal binding, enzymatic, kinetic and parasitic assays complemented with X-ray crystallography reveal compounds that are moderate in potency. Co-crystals of Cla?B and Cla?C with PfKRS reveal key atomic configurations that allow drug binding to and inhibition of the enzyme. Collectively these piperidine ring scaffold inhibitors lay a framework for further structural editing and functional modifications of the cladosporin scaffold to obtain a potent lead.

Synthetic method of isocoumarin aromatic ether compound

The invention discloses a synthetic method of an isocoumarin aromatic ether compound, which belongs to the technical field of synthesis of aromatic ether compounds, and discloses a novel aromatic ether compound, which has a specific synthetic route as fol

BIOSYNTHESIS OF CANESCIN, A METABOLITE OF ASPERGILLUS MALIGNUS : INCORPORATION OF METHIONINE, ACETATE, SUCCINATE, AND ISOCOUMARIN PRECURSORS, LABELLED WITH DEUTERIUM AND CARBON-13

The biosynthesis of canescin (1), a metabolite of Aspergillus malignus, has been studied using methionine, sodium- and acetate, and sodium- and -succinate as simple precursors, and deuterium labelled isocoumarins as potential advanced precursors.Analysis of the labelled products by both n.m.r. and mass spectrometry suggests that 6,8-dihydroxy-3,7-dimethylisocoumarin (13) is the first enzyme-free intermediate produced by the polyketide synthase, and the 7-formyl-6,8-dihydroxy-3-methylisocoumarin (16) is a later intermediate on the pathway.Incorporation into canescin of (13)C together with one deuterium atom from methionine proves that the formyl group of (16) is derived from this source and that it is not oxidised to the level of a carboxylic acid in subsequent steps.The (13)C labels in the succinate units are incorporated into the γ-lactone carbons (C-11 to C-13) of canescin, but with complete loss of the neighbouring deuterium label.