1204122-42-8

Basic information

• Product Name: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate
• CAS NO: 1204122-42-8
• Molecular Weight: 454.613
• Mol File: 1204122-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate(1204122-42-8)
• EPA Substance Registry System: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate(1204122-42-8)

Safety Data

• Hazardous Substances Data: 1204122-42-8(Hazardous Substances Data)

Upstream product

• 1204122-37-1 (2R)-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 20585-39-1 (2R)-2-Cyclohexyl-2-hydroxy-2-phenylacetic acid 
• 4335-77-7 cyclohexylmandelic acid 
• 1204122-40-6 (R)-cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol 
• 158407-04-6 tert-butyl 4-(bromomethyl)piperidine-1-carboxylate 

Downstream Products

• 1204122-44-0 (R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol 
• 1204122-61-1 2-[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperdin-1-yl]ethyl}phenyl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 1204122-67-7 (R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol 
• 1204122-69-9 8-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]quinolin-2(1H)-one 
• 1204122-71-3 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]-8-hydroxyquinolin-2(1H)-one 
• 1204123-15-8 PF-04810097 

Relevant articles and documents

Molecular hybridization yields triazole bronchodilators for the treatment of COPD

A 1,2,4-triazole motif was employed as a bioisostere for the ester commonly used in muscarinic antagonists, and subsequent integrative conjugation to a β2 agonist quinolinone furnished a new class of bifunctional MABAs for the treatment of COPD. Medicinal chemistry optimization using the principles of 'inhalation by design' furnished a clinical candidate with desirable pharmacological, pharmacokinetic and biopharmaceutical properties.