1204218-86-9Relevant articles and documents
Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors
Takahashi, Hiroyasu,Shinoyama, Mariko,Komine, Takashi,Nagao, Muneki,Suzuki, Masashi,Tsuchida, Hisatoshi,Katsuyama, Koichi
, p. 1758 - 1762 (2011/05/05)
Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.