1204312-39-9 Usage
Description
2-Acetamido-4-chloro-5-methylbenzoic acid is a chemical compound with the molecular formula C10H10N1O3Cl1. It is a derivative of acetylsalicylic acid, characterized by the presence of both acetyl and amino groups attached to a benzene ring, along with a chlorine and a methyl group. 2-acetaMido-4-chloro-5-Methylbenzoic acid serves as a versatile intermediate in the pharmaceutical industry, utilized in the synthesis of a variety of drugs due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
2-Acetamido-4-chloro-5-methylbenzoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its structural components, including the acetyl, amino, chlorine, and methyl groups, contribute to its reactivity and potential for forming diverse drug molecules.
Used in Drug Development:
As a building block in pharmaceutical chemistry, 2-acetamido-4-chloro-5-methylbenzoic acid is employed for the development of new drugs. Its unique structure may confer specific therapeutic properties, making it a valuable component in the creation of medications targeting various health conditions.
The exact applications and properties of 2-acetamido-4-chloro-5-methylbenzoic acid can vary based on the specific requirements of the pharmaceutical compounds it is used to synthesize. Its potential therapeutic uses are still under exploration, with ongoing research aimed at uncovering its full range of capabilities within the medical field.
Check Digit Verification of cas no
The CAS Registry Mumber 1204312-39-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,4,3,1 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1204312-39:
(9*1)+(8*2)+(7*0)+(6*4)+(5*3)+(4*1)+(3*2)+(2*3)+(1*9)=89
89 % 10 = 9
So 1204312-39-9 is a valid CAS Registry Number.
1204312-39-9Relevant articles and documents
BENZAMIDE DERIVATIVE
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, (2015/03/16)
The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3 H -quinazolin-6-yl)methylprop-2- ynylamino]- N -(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt)
Lockman, Jeffrey W.,Murphy, Brett R.,Zigar, Daniel F.,Judd, Weston R.,Slattum, Paul M.,Gao, Zhong-Hua,Ostanin, Kirill,Green, Jeremy,McKinnon, Rena,Terry-Lorenzo, Ryan T.,Fleischer, Tracey C.,Boniface, J. Jay,Shenderovich, Mark,Willardsen, J. Adam
experimental part, p. 8734 - 8746 (2011/02/23)
We have shown previously that the target of the potent cytotoxic agent 4-[(7-bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methyl-prop-2-ynylamino] -N-(3-pyridylmethyl)benzamide (CB38065, 1) is nicotinamide phosphoribosyltransferase (Nampt). With its cellular target known we sought to optimize the biochemical and cellular Nampt activity of 1 as well as its cytotoxicity. It was found that a 3-pyridylmethylamide substituent in the A region was critical to cellular Nampt activity and cytotoxicity, although other aromatic substitution did yield compounds with submicromolar enzymatic inhibition. Small unsaturated groups worked best in the D-region of the molecule, with 3,3-dimethylallyl providing optimal potency. The E region required a quinazolin-4-one or 1,2,3-benzotriazin-4-one group for activity, and many substituents were tolerated at C2 of the quinazolin-4-one. The best compounds showed subnanomolar inhibition of Nampt and low nanomolar cytotoxicity in cellular assays.
